2-(4-methylphenyl)spiroindene>-1',3'-dione

Base Information

• Chemical Name: 2-(4-methylphenyl)spiroindene>-1',3'-dione
• CAS No.: 114158-23-5
• Molecular Formula: C₁₈H₁₄O₂
• Molecular Weight: 262.308
• Mol file: 114158-23-5.mol

Synonyms:2-(4-methylphenyl)spiroindene>-1',3'-dione

Chemical Property of 2-(4-methylphenyl)spiroindene>-1',3'-dione

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(4-methylphenyl)spiroindene>-1',3'-dione

There total 5 articles about 2-(4-methylphenyl)spiroindene>-1',3'-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-ethenyl-4-methylbenzene (622-97-9,24936-41-2) + 1H-indene-1,3(2H)-dione (606-23-5) → 2-(4-methylphenyl)spiroindene>-1',3'-dione (114158-23-5)

Guidance literature:

With N-iodo-succinimide; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere; Irradiation;

DOI:10.1021/acs.joc.6b01163

Reference yield: 61.0%

2-(4-methyl-benzylidene)-indan-1,3-dione (15875-51-1) + trimethylsulfoxonium iodide (1774-47-6) → 2-(4-methylphenyl)spiroindene>-1',3'-dione (114158-23-5)

Guidance literature:

trimethylsulfoxonium iodide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.75h; Inert atmosphere;

2-(4-methyl-benzylidene)-indan-1,3-dione; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.833333h; Inert atmosphere;

DOI:10.1007/s10593-019-02448-y

Reference yield: 59.0%

1-ethenyl-4-methylbenzene (622-97-9,24936-41-2) + 2-diazo-indan-1,3-dione (1807-49-4) → 2-(4-methylphenyl)spiroindene>-1',3'-dione (114158-23-5)

Guidance literature:

With rhodium(II) acetate; In toluene; at 80 ℃;

DOI:10.1021/jo00247a007

upstream raw materials:

1-ethenyl-4-methylbenzene

2-diazo-indan-1,3-dione

1H-indene-1,3(2H)-dione

2-(4-methyl-benzylidene)-indan-1,3-dione