ethyl 5-((4-chloro-2-methyl-6-[methylcabamoyl]phenyl)carbamoyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-3-carboxylate

Base Information

Chemical Name:ethyl 5-((4-chloro-2-methyl-6-[methylcabamoyl]phenyl)carbamoyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-3-carboxylate
CAS No.:1257069-31-0
Molecular Formula:C₂₁H₁₉Cl₂N₅O₄
Molecular Weight:476.319
Hs Code.:

Synonyms:ethyl 5-((4-chloro-2-methyl-6-[methylcabamoyl]phenyl)carbamoyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-3-carboxylate

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Chemical Property of ethyl 5-((4-chloro-2-methyl-6-[methylcabamoyl]phenyl)carbamoyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-3-carboxylate

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Technology Process of ethyl 5-((4-chloro-2-methyl-6-[methylcabamoyl]phenyl)carbamoyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-3-carboxylate

There total 8 articles about ethyl 5-((4-chloro-2-methyl-6-[methylcabamoyl]phenyl)carbamoyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1257070-45-3
1-(3-chloro-2-pyridinyl)-3-ethoxycarbonyl-1H-pyrazole-5-carboxylic acid

: 20776-67-4
2-amino-5-chloro-3-methylbenzoic acid

: 74-89-5
methylamine

: 1257069-31-0
ethyl 5-((4-chloro-2-methyl-6-[methylcabamoyl]phenyl)carbamoyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-3-carboxylate

Guidance literature:: 1-(3-chloro-2-pyridinyl)-3-ethoxycarbonyl-1H-pyrazole-5-carboxylic acid; 2-amino-5-chloro-3-methylbenzoic acid; With pyridine; methanesulfonyl chloride; In acetonitrile; at 20 ℃; for 2h;

methylamine; In water; acetonitrile; at -5 ℃; for 2h;
DOI:10.1002/jhet.4422

Reference yield:

: 1033344-58-9
ethyl 1-(3-chloropyridin-2-yl)-5-(furan-2-yl)-1H-pyrazole-3-carboxylate

: 1257069-31-0
ethyl 5-((4-chloro-2-methyl-6-[methylcabamoyl]phenyl)carbamoyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium permanganate / water; acetone / 0.5 h / Reflux

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

3: pyridine / 1 h / 20 °C

With pyridine; potassium permanganate; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; water; acetone;
DOI:10.1021/jf102842r

Reference yield:

: 412304-91-7
ethyl 4-(2-furyl)-2,4-dioxobutanoate

: 1257069-31-0
ethyl 5-((4-chloro-2-methyl-6-[methylcabamoyl]phenyl)carbamoyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 0.5 h / Reflux

2.1: potassium dihydrogenphosphate / acetone; water / -5 °C

2.2: 12 h / -5 °C

3.1: methanesulfonyl chloride; pyridine / acetonitrile / 2 h / 20 °C

3.2: 2 h / -5 °C

With pyridine; potassium dihydrogenphosphate; acetic acid; methanesulfonyl chloride; In water; acetone; acetonitrile;
DOI:10.1002/jhet.4422