6-<<3-(benzyloxy)propoxy>amino>-4-chloro-5-formamidopyrimidine

Base Information

• Chemical Name: 6-<<3-(benzyloxy)propoxy>amino>-4-chloro-5-formamidopyrimidine
• CAS No.: 123240-67-5
• Molecular Formula: C₁₅H₁₇ClN₄O₃
• Molecular Weight: 336.778
• Mol file: 123240-67-5.mol

Synonyms:6-<<3-(benzyloxy)propoxy>amino>-4-chloro-5-formamidopyrimidine

Chemical Property of 6-<<3-(benzyloxy)propoxy>amino>-4-chloro-5-formamidopyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 6-<<3-(benzyloxy)propoxy>amino>-4-chloro-5-formamidopyrimidine

There total 1 articles about 6-<<3-(benzyloxy)propoxy>amino>-4-chloro-5-formamidopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4,6-dichloro-5-formamidopyrimidine (123240-66-4) + 3-(benzyloxy)propoxyamine (114809-62-0) → 6-<<3-(benzyloxy)propoxy>amino>-4-chloro-5-formamidopyrimidine (123240-67-5)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 110 ℃; for 6h;

DOI:10.1021/jm00163a031

Reference yield: 98.0%

6-<<3-(benzyloxy)propoxy>amino>-4-chloro-5-formamidopyrimidine (123240-67-5) → 9-<3-(benzyloxy)propoxy>-6-chloropurine (123240-68-6)

Guidance literature:

With hydrogenchloride; orthoformic acid triethyl ester; In N,N-dimethyl-formamide; for 16h; Ambient temperature;

DOI:10.1021/jm00163a031

Reference yield:

6-<<3-(benzyloxy)propoxy>amino>-4-chloro-5-formamidopyrimidine (123240-67-5) → 9-<3-(benzyloxy)propoxy>adenine (123240-77-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / triethyl orthoformate, 12N HCl / dimethylformamide / 16 h / Ambient temperature

2: 17 percent / NH₃ / methanol / 48 h / 110 °C / autoclave

With hydrogenchloride; ammonia; orthoformic acid triethyl ester; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00163a031

upstream raw materials:

4,6-dichloro-5-formamidopyrimidine

3-(benzyloxy)propoxyamine

Downstream raw materials:

9-<3-(benzyloxy)propoxy>-6-chloropurine

9-<3-(benzyloxy)propoxy>adenine