N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-methyl-6-(4-morpholinylcarbonyl)-2-pyrimidinamine

Base Information

Chemical Name:N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-methyl-6-(4-morpholinylcarbonyl)-2-pyrimidinamine
CAS No.:169882-87-5
Molecular Formula:C₂₁H₂₇BrN₄O₂
Molecular Weight:447.375
Hs Code.:

Synonyms:N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-methyl-6-(4-morpholinylcarbonyl)-2-pyrimidinamine

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Chemical Property of N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-methyl-6-(4-morpholinylcarbonyl)-2-pyrimidinamine

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Technology Process of N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-methyl-6-(4-morpholinylcarbonyl)-2-pyrimidinamine

There total 4 articles about N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-methyl-6-(4-morpholinylcarbonyl)-2-pyrimidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 110-91-8,99108-56-2
morpholine

: 169880-48-2
methyl 2-((2-bromo-4-(1-methylethyl)phenyl)ethylamino)-6-methyl-4-pyrimidinecarboxylate

: 169882-87-5
N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-methyl-6-(4-morpholinylcarbonyl)-2-pyrimidinamine

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 17h; Heating;
DOI:10.1016/S0968-0896(99)00182-0

Reference yield:

: 51605-97-1
2-bromo-4-isopropylaniline

: 169882-87-5
N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-methyl-6-(4-morpholinylcarbonyl)-2-pyrimidinamine

Guidance literature:: Multi-step reaction with 3 steps

1: 53 percent / dioxane / 24 h / Heating

2: 55 percent / NaH / dimethylformamide / 5 h

3: 39 percent / NaH / tetrahydrofuran / 17 h / Heating

With sodium hydride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 1: Alkylation / 2: Alkylation / 3: Substitution;
DOI:10.1016/S0968-0896(99)00182-0

Reference yield:

: 89793-11-3
methyl 2-chloro-6-methylpyrimidine-4-carboxylate

: 169882-87-5
N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-methyl-6-(4-morpholinylcarbonyl)-2-pyrimidinamine

Guidance literature:: Multi-step reaction with 3 steps

1: 53 percent / dioxane / 24 h / Heating

2: 55 percent / NaH / dimethylformamide / 5 h

3: 39 percent / NaH / tetrahydrofuran / 17 h / Heating

With sodium hydride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 1: Alkylation / 2: Alkylation / 3: Substitution;
DOI:10.1016/S0968-0896(99)00182-0