(4S)-4-[(benzyloxycarbonyl)amino]tetrahydro-2-methyl-3-oxo-1(2H)-pyridazinecarbonitrile

Base Information

Chemical Name:(4S)-4-[(benzyloxycarbonyl)amino]tetrahydro-2-methyl-3-oxo-1(2H)-pyridazinecarbonitrile
CAS No.:1417900-19-6
Molecular Formula:C₁₄H₁₆N₄O₃
Molecular Weight:288.306
Hs Code.:

Synonyms:(4S)-4-[(benzyloxycarbonyl)amino]tetrahydro-2-methyl-3-oxo-1(2H)-pyridazinecarbonitrile

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Chemical Property of (4S)-4-[(benzyloxycarbonyl)amino]tetrahydro-2-methyl-3-oxo-1(2H)-pyridazinecarbonitrile

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Technology Process of (4S)-4-[(benzyloxycarbonyl)amino]tetrahydro-2-methyl-3-oxo-1(2H)-pyridazinecarbonitrile

There total 7 articles about (4S)-4-[(benzyloxycarbonyl)amino]tetrahydro-2-methyl-3-oxo-1(2H)-pyridazinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 506-68-3
bromocyane

: 1417900-13-0
(4S)-4-[(benzyloxycarbonyl)amino]-2-methyl-tetrahydro-3(2H)-pyridazinone

: 1417900-19-6
(4S)-4-[(benzyloxycarbonyl)amino]tetrahydro-2-methyl-3-oxo-1(2H)-pyridazinecarbonitrile

Guidance literature:: With sodium acetate; In methanol; at 20 ℃; for 5.5h;
DOI:10.1021/ol3030583

Reference yield:

: (4S)-4-[(benzyloxycarbonyl)amino]-2-methyl-4,5-dihydro-3(2H)-pyridazinone

: 1417900-19-6
(4S)-4-[(benzyloxycarbonyl)amino]tetrahydro-2-methyl-3-oxo-1(2H)-pyridazinecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: sodium cyanoborohydride / methanol; acetic acid / 0 - 20 °C

2: sodium acetate / methanol / 5.5 h / 20 °C

With sodium acetate; sodium cyanoborohydride; In methanol; acetic acid;
DOI:10.1021/ol3030583

Reference yield:

: 60684-59-5
methyl (S)-2-(((benzyloxy)carbonyl)amino)-4-oxobutanoate

: 1417900-19-6
(4S)-4-[(benzyloxycarbonyl)amino]tetrahydro-2-methyl-3-oxo-1(2H)-pyridazinecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 23 h / 20 °C / Reflux

2: sodium cyanoborohydride / methanol; acetic acid / 0 - 20 °C

3: sodium acetate / methanol / 5.5 h / 20 °C

With sodium acetate; sodium cyanoborohydride; In methanol; ethanol; acetic acid;
DOI:10.1021/ol3030583