(4S)-4-[(benzyloxycarbonyl)amino]-2-methyl-tetrahydro-3(2H)-pyridazinone

Base Information

Chemical Name:(4S)-4-[(benzyloxycarbonyl)amino]-2-methyl-tetrahydro-3(2H)-pyridazinone
CAS No.:1417900-13-0
Molecular Formula:C₁₃H₁₇N₃O₃
Molecular Weight:263.296
Hs Code.:

Synonyms:(4S)-4-[(benzyloxycarbonyl)amino]-2-methyl-tetrahydro-3(2H)-pyridazinone

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Chemical Property of (4S)-4-[(benzyloxycarbonyl)amino]-2-methyl-tetrahydro-3(2H)-pyridazinone

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Technology Process of (4S)-4-[(benzyloxycarbonyl)amino]-2-methyl-tetrahydro-3(2H)-pyridazinone

There total 6 articles about (4S)-4-[(benzyloxycarbonyl)amino]-2-methyl-tetrahydro-3(2H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: (4S)-4-[(benzyloxycarbonyl)amino]-2-methyl-4,5-dihydro-3(2H)-pyridazinone

: 1417900-13-0
(4S)-4-[(benzyloxycarbonyl)amino]-2-methyl-tetrahydro-3(2H)-pyridazinone

Guidance literature:: With sodium cyanoborohydride; In methanol; acetic acid; at 0 - 20 ℃;
DOI:10.1021/ol3030583

Reference yield:

: 60684-59-5
methyl (S)-2-(((benzyloxy)carbonyl)amino)-4-oxobutanoate

: 1417900-13-0
(4S)-4-[(benzyloxycarbonyl)amino]-2-methyl-tetrahydro-3(2H)-pyridazinone

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 23 h / 20 °C / Reflux

2: sodium cyanoborohydride / methanol; acetic acid / 0 - 20 °C

With sodium cyanoborohydride; In methanol; ethanol; acetic acid;
DOI:10.1021/ol3030583

Reference yield:

: 4668-37-5
N-(benzyloxycarbonyl)asparagine methyl ester

: 1417900-13-0
(4S)-4-[(benzyloxycarbonyl)amino]-2-methyl-tetrahydro-3(2H)-pyridazinone

Guidance literature:: Multi-step reaction with 5 steps

1: tert.-butylnitrite / acetonitrile / 1.5 h / Reflux

2: borane-THF / tetrahydrofuran / 6 h / -5 - 20 °C

3: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

4: ethanol / 23 h / 20 °C / Reflux

5: sodium cyanoborohydride / methanol; acetic acid / 0 - 20 °C

With tert.-butylnitrite; borane-THF; sodium cyanoborohydride; Dess-Martin periodane; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetic acid; acetonitrile; 3: |Dess-Martin Oxidation;
DOI:10.1021/ol3030583