ethyl 5-(4-(N,N-dimethylamino)phenyl)oxazole-4-carboxylate

Base Information

• Chemical Name: ethyl 5-(4-(N,N-dimethylamino)phenyl)oxazole-4-carboxylate
• CAS No.: 1283902-09-9
• Molecular Formula: C₁₄H₁₆N₂O₃
• Molecular Weight: 260.293
• Mol file: 1283902-09-9.mol

Synonyms:ethyl 5-(4-(N,N-dimethylamino)phenyl)oxazole-4-carboxylate

Chemical Property of ethyl 5-(4-(N,N-dimethylamino)phenyl)oxazole-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-(4-(N,N-dimethylamino)phenyl)oxazole-4-carboxylate

There total 2 articles about ethyl 5-(4-(N,N-dimethylamino)phenyl)oxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-(dimethylamino)benzoyl chloride (4755-50-4) + Ethyl isocyanoacetate (2999-46-4) → ethyl 5-(4-(N,N-dimethylamino)phenyl)oxazole-4-carboxylate (1283902-09-9)

Guidance literature:

Ethyl isocyanoacetate; With potassium tert-butylate; In tetrahydrofuran; Inert atmosphere; Cooling with ice;

4-(dimethylamino)benzoyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1039/c1ob05261f

Reference yield: 33.0%

oxazole-4-carboxylic acid ethyl ester (23012-14-8) + 4-bromo-N,N-dimethylaniline (586-77-6) → C20H15NO5 (1055195-15-7) + ethyl 5-(4-(N,N-dimethylamino)phenyl)oxazole-4-carboxylate (1283902-09-9)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; potassium carbonate; In 1,4-dioxane; at 110 ℃; for 18h; regioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201101615

Reference yield: 99.0%

ethyl 5-(4-(N,N-dimethylamino)phenyl)oxazole-4-carboxylate (1283902-09-9) + ethyl [2-(4-chlorophenyl)-5-(4-(dimethylamino)phenyl)]oxazole-4-carboxylate (1334553-33-1) → C34H34N4O6 (1334553-37-5)

Guidance literature:

With palladium diacetate; caesium carbonate; CyJohnPhos; In 1,4-dioxane; at 110 ℃; for 18h; Inert atmosphere;

DOI:10.1039/c1ob05261f

upstream raw materials:

4-(dimethylamino)benzoyl chloride

Ethyl isocyanoacetate

oxazole-4-carboxylic acid ethyl ester

4-bromo-N,N-dimethylaniline

Downstream raw materials:

C₃₃H₂₈N₄O₆

C₃₄H₃₄N₄O₆

C₃₁H₂₈N₄O₆

ethyl [2-(4-chlorophenyl)-5-(4-(dimethylamino)phenyl)]oxazole-4-carboxylate