3-(5-(2-((4'-chloro-2'-methyl-[1,1'-biphenyl]-4-yl)carbamoyl)-5-(trifluoromethyl)phenyl)picolinamido)propanoic acid

Base Information

Chemical Name:3-(5-(2-((4'-chloro-2'-methyl-[1,1'-biphenyl]-4-yl)carbamoyl)-5-(trifluoromethyl)phenyl)picolinamido)propanoic acid
CAS No.:1415128-91-4
Molecular Formula:C₃₀H₂₃ClF₃N₃O₄
Molecular Weight:581.979
Hs Code.:

Synonyms:3-(5-(2-((4'-chloro-2'-methyl-[1,1'-biphenyl]-4-yl)carbamoyl)-5-(trifluoromethyl)phenyl)picolinamido)propanoic acid

Suppliers and Price of 3-(5-(2-((4'-chloro-2'-methyl-[1,1'-biphenyl]-4-yl)carbamoyl)-5-(trifluoromethyl)phenyl)picolinamido)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(5-(2-((4'-chloro-2'-methyl-[1,1'-biphenyl]-4-yl)carbamoyl)-5-(trifluoromethyl)phenyl)picolinamido)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(5-(2-((4'-chloro-2'-methyl-[1,1'-biphenyl]-4-yl)carbamoyl)-5-(trifluoromethyl)phenyl)picolinamido)propanoic acid

There total 7 articles about 3-(5-(2-((4'-chloro-2'-methyl-[1,1'-biphenyl]-4-yl)carbamoyl)-5-(trifluoromethyl)phenyl)picolinamido)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415130-72-1
ethyl 3-(5-(2-((4'-chloro-2'-methyl-[1,1'-biphenyl]-4-yl)carbamoyl)-5-(trifluoromethyl)phenyl)picolinamido)propanoate

: 1415128-91-4
3-(5-(2-((4'-chloro-2'-methyl-[1,1'-biphenyl]-4-yl)carbamoyl)-5-(trifluoromethyl)phenyl)picolinamido)propanoic acid

Guidance literature:: ethyl 3-(5-(2-((4'-chloro-2'-methyl-[1,1'-biphenyl]-4-yl)carbamoyl)-5-(trifluoromethyl)phenyl)picolinamido)propanoate; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield:

: 209919-30-2
4-chloro-2-methylphenylboronic acid

: 1415128-91-4
3-(5-(2-((4'-chloro-2'-methyl-[1,1'-biphenyl]-4-yl)carbamoyl)-5-(trifluoromethyl)phenyl)picolinamido)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / 1,4-dioxane; water / 3 h / 90 °C

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

3: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

With water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 540-37-4
p-aminoiodobenzene

: 1415128-91-4
3-(5-(2-((4'-chloro-2'-methyl-[1,1'-biphenyl]-4-yl)carbamoyl)-5-(trifluoromethyl)phenyl)picolinamido)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / 1,4-dioxane; water / 3 h / 90 °C

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

3: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

With water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;