tert-butyl (S)-1-(methoxycarbonyl)-5-(1-(2-morpholinopyrimidin-N-yl)amino)pentylcarbamate

Base Information

Chemical Name:tert-butyl (S)-1-(methoxycarbonyl)-5-(1-(2-morpholinopyrimidin-N-yl)amino)pentylcarbamate
CAS No.:1332525-44-6
Molecular Formula:C₂₀H₃₃N₅O₅
Molecular Weight:423.513
Hs Code.:

Synonyms:tert-butyl (S)-1-(methoxycarbonyl)-5-(1-(2-morpholinopyrimidin-N-yl)amino)pentylcarbamate

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Chemical Property of tert-butyl (S)-1-(methoxycarbonyl)-5-(1-(2-morpholinopyrimidin-N-yl)amino)pentylcarbamate

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Technology Process of tert-butyl (S)-1-(methoxycarbonyl)-5-(1-(2-morpholinopyrimidin-N-yl)amino)pentylcarbamate

There total 1 articles about tert-butyl (S)-1-(methoxycarbonyl)-5-(1-(2-morpholinopyrimidin-N-yl)amino)pentylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1332525-41-3
1-(2-morpholinopyrimidin-4yloxy)-1H-benzo[d]-[1,2,3] triazole

: 55757-60-3
N-α-(tert-butoxycarbonyl)-L-lysine methyl ester

: 1332525-44-6
tert-butyl (S)-1-(methoxycarbonyl)-5-(1-(2-morpholinopyrimidin-N-yl)amino)pentylcarbamate

Guidance literature:: N-α-(tert-butoxycarbonyl)-L-lysine methyl ester; With potassium carbonate; In acetonitrile; at 20 ℃; for 0.25h;

1-(2-morpholinopyrimidin-4yloxy)-1H-benzo[d]-[1,2,3] triazole; In acetonitrile; at 40 ℃; for 24h;
DOI:10.1039/c1ob05313b

Reference yield:

: 1332525-44-6
tert-butyl (S)-1-(methoxycarbonyl)-5-(1-(2-morpholinopyrimidin-N-yl)amino)pentylcarbamate

: 1332525-53-7
C₂₃H₃₃N₇O₃

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 20 °C

1.2: pH 4

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

With lithium hydroxide monohydrate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1039/c1ob05313b

Reference yield:

: 1332525-44-6
tert-butyl (S)-1-(methoxycarbonyl)-5-(1-(2-morpholinopyrimidin-N-yl)amino)pentylcarbamate

: 1332525-54-8
C₂₃H₃₃N₇O₃

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 20 °C

1.2: pH 4

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

With lithium hydroxide monohydrate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1039/c1ob05313b