BOC-LYS(AC)-OH HCL

Base Information

• Chemical Name: BOC-LYS(AC)-OH HCL
• CAS No.: 55757-60-3
• Molecular Formula: C12H24N2O4^.HCl
• Molecular Weight: 260.334
• Hs Code.: 2924199090
• Mol file: 55757-60-3.mol

Synonyms:N-tert-Butoxycarbonyl-L-lysinemethyl ester;methyl N2-(tert-butoxycarbonyl)-L-lysinate hydrochloride;L-Lysine, N2-[(1,1-dimethylethoxy)carbonyl]-, methyl ester, hydrochloride (1:1);Methyl N2-(tert-butoxycarbonyl)-L-lysinate hydrochloride (1:1);methyl (2S)-6-amino-2-{[(tert-butoxy)carbonyl]amino}hexanoate hydrochloride;N-Boc-L-lysine methyl ester hydrochloride;

Chemical Property of BOC-LYS(AC)-OH HCL

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.466
• Boiling Point: 404.4 °C at 760 mmHg
• PKA: 11.16±0.46(Predicted)
• Flash Point: 198.4 °C
• PSA: 90.65000
• Density: 1.056g/cm3
• LogP: 3.07490
• Storage Temp.: Store at 0°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Boc-L-LysineMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Boc-L-Lysine Methyl Ester is a reagent in the synthesis of myxochelin analogs as antimetastatic agents.

Technology Process of BOC-LYS(AC)-OH HCL

There total 16 articles about BOC-LYS(AC)-OH HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Boc-L-Lys(Z)-OMe (73548-77-3) → N-α-(tert-butoxycarbonyl)-L-lysine methyl ester (55757-60-3)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 0.666667h;

Reference yield: 90.0%

methyl 6-N-benzyloxycarbonyl-2-N-BOC-D-lysinate (82611-49-2) → methyl (2R)-6-amino-2-{[(tert-butoxy)carbonyl]amino}hexanoate (55757-60-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 14h;

DOI:10.3184/174751915X14326563172262

Reference yield: 82.0%

(S)-2-tert-Butoxycarbonylamino-6-[(pyridine-2-carbonyl)-amino]-hexanoic acid methyl ester → N-α-(tert-butoxycarbonyl)-L-lysine methyl ester (55757-60-3)

Guidance literature:

With sodium hydroxide; sulfuric acid; In methanol; water; at 25 ℃; pH=2.0, electrochemical reduction;

DOI:10.1016/S0040-4039(97)00362-6

upstream raw materials:

Boc-L-Lys(Z)-OMe

N^α-(tert-butoxycarbonyl)-N^ε-(tert-butyldimethylsilyloxycarbonyl)-L-lysine methyl ester

Boc-Lys(Z)-OH

methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride

Downstream raw materials:

2-tert-Butoxycarbonylamino-6-((8R,9S,13S,14S,17R)-3-hydroxy-13-methyl-16-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ylamino)-hexanoic acid methyl ester

(S)-2-tert-Butoxycarbonylamino-6-[3-(4-methyl-pyridin-3-yl)-propionylamino]-hexanoic acid methyl ester

(S)-6-(5-dimethylaminonaphthalene-1-sulfonylamino)-2-(tert-butoxycarbonyl)amino hexanoic acid methyl ester

2-tert-Butoxycarbonylamino-6-((8R,9S,13S,14S,17R)-3-hydroxy-13-methyl-16-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ylamino)-hexanoic acid

Refernces

• 1、 -. "Preparation method of N2-(tert-butoxycarbonyl)-L-lysine methyl ester hydrochloride". Paragraph 0006; 0023-0024; 0025-0026; 0027-0028; 0029-0030. . Retrieved 2021/04/26.
• 2、 -. "PCSK9 ANTAGONIST COMPOUNDS". Page/Page column 88; 89. . Retrieved 2021/03/05.