ethyl 2-cyano-3-((3-methyl-1-phenylpyrazol-5-ylamino)methylene)acrylate

Base Information

• Chemical Name: ethyl 2-cyano-3-((3-methyl-1-phenylpyrazol-5-ylamino)methylene)acrylate
• CAS No.: 110299-42-8
• Molecular Formula: C₁₆H₁₆N₄O₂
• Molecular Weight: 296.329

Synonyms:ethyl 2-cyano-3-((3-methyl-1-phenylpyrazol-5-ylamino)methylene)acrylate

Chemical Property of ethyl 2-cyano-3-((3-methyl-1-phenylpyrazol-5-ylamino)methylene)acrylate

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Technology Process of ethyl 2-cyano-3-((3-methyl-1-phenylpyrazol-5-ylamino)methylene)acrylate

There total 2 articles about ethyl 2-cyano-3-((3-methyl-1-phenylpyrazol-5-ylamino)methylene)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-Phenyl-3-methyl-5-aminopyrazole (1131-18-6) + ethyl (ethoxymethylene)cyanoacetate (94-05-3,42466-69-3) → ethyl 2-cyano-3-((3-methyl-1-phenylpyrazol-5-ylamino)methylene)acrylate (110299-42-8)

Guidance literature:

In ethanol; for 2h; Heating;

DOI:10.1002/jccs.200700072

Reference yield:

phenylhydrazine (100-63-0) → ethyl 2-cyano-3-((3-methyl-1-phenylpyrazol-5-ylamino)methylene)acrylate (110299-42-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 7 h / Reflux

2: ethanol / 2 h / Reflux

In ethanol;

DOI:10.21577/0103-5053.20170126

Reference yield: 95.0%

ethyl 2-cyano-3-((3-methyl-1-phenylpyrazol-5-ylamino)methylene)acrylate (110299-42-8) → 4-hydroxy-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile

Guidance literature:

In tetrahydrofuran; at 390 ℃; under 75007.5 Torr;

DOI:10.1021/acs.joc.6b02520

upstream raw materials:

1-Phenyl-3-methyl-5-aminopyrazole

ethyl (ethoxymethylene)cyanoacetate

phenylhydrazine

Downstream raw materials:

3-methyl-4-oxo-1-phenyl-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile

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