4-({[4-(trifluoromethoxy)benzyl][4-(trifluoromethyl)isoquinolin-3-yl]amino}sulfonyl)benzamide

Base Information

Chemical Name:4-({[4-(trifluoromethoxy)benzyl][4-(trifluoromethyl)isoquinolin-3-yl]amino}sulfonyl)benzamide
CAS No.:1400701-23-6
Molecular Formula:C₂₅H₁₇F₆N₃O₄S
Molecular Weight:569.484
Hs Code.:

Synonyms:4-({[4-(trifluoromethoxy)benzyl][4-(trifluoromethyl)isoquinolin-3-yl]amino}sulfonyl)benzamide

Suppliers and Price of 4-({[4-(trifluoromethoxy)benzyl][4-(trifluoromethyl)isoquinolin-3-yl]amino}sulfonyl)benzamide

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Chemical Property of 4-({[4-(trifluoromethoxy)benzyl][4-(trifluoromethyl)isoquinolin-3-yl]amino}sulfonyl)benzamide

Chemical Property:

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Technology Process of 4-({[4-(trifluoromethoxy)benzyl][4-(trifluoromethyl)isoquinolin-3-yl]amino}sulfonyl)benzamide

There total 9 articles about 4-({[4-(trifluoromethoxy)benzyl][4-(trifluoromethyl)isoquinolin-3-yl]amino}sulfonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: sodium 4-({[4-(trifluoromethoxy)benzyl][4-(trifluoromethyl)isoquinolin-3-yl]amino}sulfonyl)benzoate

: 1400701-23-6
4-({[4-(trifluoromethoxy)benzyl][4-(trifluoromethyl)isoquinolin-3-yl]amino}sulfonyl)benzamide

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃;

Reference yield:

: C₂₅H₁₅ClF₆N₂O₄S

: 1400701-23-6
4-({[4-(trifluoromethoxy)benzyl][4-(trifluoromethyl)isoquinolin-3-yl]amino}sulfonyl)benzamide

Guidance literature:: With ammonium hydroxide; at 20 ℃; for 3h;

Reference yield:

: 25475-67-6
isoquinolin-3-amine

: 1400701-23-6
4-({[4-(trifluoromethoxy)benzyl][4-(trifluoromethyl)isoquinolin-3-yl]amino}sulfonyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 4 h / 20 °C

2: N-iodo-succinimide; acetic acid / N,N-dimethyl-formamide / 0.25 h / 50 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C

4: copper(l) iodide; N,N,N,N,N,N-hexamethylphosphoric triamide / N,N-dimethyl-formamide / 5 h / 70 °C / Inert atmosphere

5: sodium hydroxide / tetrahydrofuran; ethanol; water / 1 h / 20 °C

6: N,N-dimethyl-formamide; oxalyl dichloride / tetrahydrofuran / 20 °C

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; copper(l) iodide; oxalyl dichloride; potassium carbonate; acetic acid; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;