ethyl 4-({(4-iodoisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate

Base Information

Chemical Name:ethyl 4-({(4-iodoisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate
CAS No.:1400702-34-2
Molecular Formula:C₂₆H₂₀F₃IN₂O₅S
Molecular Weight:656.421
Hs Code.:

Synonyms:ethyl 4-({(4-iodoisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate

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Chemical Property of ethyl 4-({(4-iodoisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate

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Technology Process of ethyl 4-({(4-iodoisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate

There total 4 articles about ethyl 4-({(4-iodoisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1400702-34-2
ethyl 4-({(4-iodoisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate

Guidance literature:

Reference yield: 78.0%

: 1400702-33-1
ethyl 4-{[(4-iodoisoquinolin-3-yl)amino]sulfonyl}benzoate

: 50824-05-0
4-trifluoromethoxybenzyl bromide

: 1400702-34-2
ethyl 4-({(4-iodoisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 3h;

Reference yield:

: 10486-51-8
4-ethoxycarbonylbenzenesulfonyl chloride

: 1400702-34-2
ethyl 4-({(4-iodoisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 4 h / 20 °C

2: N-iodo-succinimide; acetic acid / N,N-dimethyl-formamide / 0.25 h / 50 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C

With pyridine; N-iodo-succinimide; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;