ethyl 4-({[4-(trifluoromethoxy)benzyl][4-(trifluoromethyl)isoquinolin-3-yl]amino}sulfonyl)benzoate

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Chemical Name:ethyl 4-({[4-(trifluoromethoxy)benzyl][4-(trifluoromethyl)isoquinolin-3-yl]amino}sulfonyl)benzoate
CAS No.:1400699-65-1
Molecular Formula:C₂₇H₂₀F₆N₂O₅S
Molecular Weight:598.523
Hs Code.:

Synonyms:ethyl 4-({[4-(trifluoromethoxy)benzyl][4-(trifluoromethyl)isoquinolin-3-yl]amino}sulfonyl)benzoate

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Chemical Property of ethyl 4-({[4-(trifluoromethoxy)benzyl][4-(trifluoromethyl)isoquinolin-3-yl]amino}sulfonyl)benzoate

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Technology Process of ethyl 4-({[4-(trifluoromethoxy)benzyl][4-(trifluoromethyl)isoquinolin-3-yl]amino}sulfonyl)benzoate

There total 6 articles about ethyl 4-({[4-(trifluoromethoxy)benzyl][4-(trifluoromethyl)isoquinolin-3-yl]amino}sulfonyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 680-15-9
2,2-difluoro-2-(fluorosulfonyl)acetate

: 1400702-34-2
ethyl 4-({(4-iodoisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate

: 1400699-65-1
ethyl 4-({[4-(trifluoromethoxy)benzyl][4-(trifluoromethyl)isoquinolin-3-yl]amino}sulfonyl)benzoate

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide; In N,N-dimethyl-formamide; at 70 ℃; for 5h; Inert atmosphere;

Reference yield: 90.0%

: 1400699-65-1
ethyl 4-({[4-(trifluoromethoxy)benzyl][4-(trifluoromethyl)isoquinolin-3-yl]amino}sulfonyl)benzoate

Guidance literature:

Reference yield:

: 10486-51-8
4-ethoxycarbonylbenzenesulfonyl chloride

: 1400699-65-1
ethyl 4-({[4-(trifluoromethoxy)benzyl][4-(trifluoromethyl)isoquinolin-3-yl]amino}sulfonyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 4 h / 20 °C

2: N-iodo-succinimide; acetic acid / N,N-dimethyl-formamide / 0.25 h / 50 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C

4: copper(l) iodide; N,N,N,N,N,N-hexamethylphosphoric triamide / N,N-dimethyl-formamide / 5 h / 70 °C / Inert atmosphere

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; copper(l) iodide; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;