4-[(4-cyano-phenoxy)-hydroxy-phosphoryl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid

Base Information

Chemical Name:4-[(4-cyano-phenoxy)-hydroxy-phosphoryl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid
CAS No.:910035-31-3
Molecular Formula:C₁₉H₁₈N₃O₉P
Molecular Weight:463.34
Hs Code.:

Synonyms:4-[(4-cyano-phenoxy)-hydroxy-phosphoryl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid

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Chemical Property of 4-[(4-cyano-phenoxy)-hydroxy-phosphoryl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid

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Technology Process of 4-[(4-cyano-phenoxy)-hydroxy-phosphoryl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid

There total 5 articles about 4-[(4-cyano-phenoxy)-hydroxy-phosphoryl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 910035-16-4
ethyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-[bis(4-cyanophenyl)phosphono]butanoate

: 910035-31-3
4-[(4-cyano-phenoxy)-hydroxy-phosphoryl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 24h;
DOI:10.1016/j.bmc.2006.05.008

Reference yield:

: 288607-57-8
2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoic acid

: 910035-31-3
4-[(4-cyano-phenoxy)-hydroxy-phosphoryl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / thionyl chloride / 76 h / 20 °C

2: thionyl chloride; dimethylformamide / 1 h / 60 °C

3: NaH / tetrahydrofuran / 0 - 20 °C

4: 56 percent / NaOH / H₂O; tetrahydrofuran / 24 h / 20 °C

With sodium hydroxide; thionyl chloride; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; water;
DOI:10.1016/j.bmc.2006.05.008

Reference yield:

: 910035-12-0
C₁₄H₁₇Cl₂N₂O₇P

: 910035-31-3
4-[(4-cyano-phenoxy)-hydroxy-phosphoryl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran / 0 - 20 °C

2: 56 percent / NaOH / H₂O; tetrahydrofuran / 24 h / 20 °C

With sodium hydroxide; sodium hydride; In tetrahydrofuran; water;
DOI:10.1016/j.bmc.2006.05.008