ethyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-[bis(4-cyanophenyl)phosphono]butanoate

Base Information

• Chemical Name: ethyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-[bis(4-cyanophenyl)phosphono]butanoate
• CAS No.: 910035-16-4
• Molecular Formula: C₂₈H₂₅N₄O₉P
• Molecular Weight: 592.502
• Mol file: 910035-16-4.mol

Synonyms:ethyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-[bis(4-cyanophenyl)phosphono]butanoate

Chemical Property of ethyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-[bis(4-cyanophenyl)phosphono]butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-[bis(4-cyanophenyl)phosphono]butanoate

There total 4 articles about ethyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-[bis(4-cyanophenyl)phosphono]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H17Cl2N2O7P (910035-12-0) + 4-cyanophenol (767-00-0) → ethyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-[bis(4-cyanophenyl)phosphono]butanoate (910035-16-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2006.05.008

Reference yield:

2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoic acid (288607-57-8) → ethyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-[bis(4-cyanophenyl)phosphono]butanoate (910035-16-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / thionyl chloride / 76 h / 20 °C

2: thionyl chloride; dimethylformamide / 1 h / 60 °C

3: NaH / tetrahydrofuran / 0 - 20 °C

With thionyl chloride; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran;

DOI:10.1016/j.bmc.2006.05.008

Reference yield:

ethyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoate (910035-10-8) → ethyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-[bis(4-cyanophenyl)phosphono]butanoate (910035-16-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride; dimethylformamide / 1 h / 60 °C

2: NaH / tetrahydrofuran / 0 - 20 °C

With thionyl chloride; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran;

DOI:10.1016/j.bmc.2006.05.008

upstream raw materials:

C₁₄H₁₇Cl₂N₂O₇P

4-cyanophenol

2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoic acid

ethyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoate

Downstream raw materials:

4-[(4-cyano-phenoxy)-hydroxy-phosphoryl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid