2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoic acid

Base Information

• Chemical Name: 2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoic acid
• CAS No.: 288607-57-8
• Molecular Formula: C₁₂H₁₅N₂O₉P
• Molecular Weight: 362.233
• Mol file: 288607-57-8.mol

Synonyms:2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoic acid

Chemical Property of 2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoic acid

There total 1 articles about 2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-amino-4-phosphonobutyric acid (6323-99-5) + 4-nitrobenzyl chloroformate (4457-32-3) → 2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoic acid (288607-57-8)

Guidance literature:

With sodium hydroxide; sodium hydrogencarbonate; In diethyl ether; water; at 20 ℃; for 26h;

DOI:10.1016/j.bmc.2006.05.008

Reference yield: 75.0%

2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoic acid (288607-57-8) + ethanol (64-17-5) → ethyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoate (910035-10-8)

Guidance literature:

With thionyl chloride; at 20 ℃; for 76h;

DOI:10.1016/j.bmc.2006.05.008

Reference yield:

2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoic acid (288607-57-8) → 4-[(4-acetyl-phenoxy)-hydroxy-phosphoryl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid (910035-29-9)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / 76 h / 20 °C

2: oxalyl chloride; dimethylformamide / CH₂Cl₂ / 2 h / Heating

3: 85 percent / NaH / tetrahydrofuran / 0 - 20 °C

4: NaOH / H₂O; tetrahydrofuran / 15 h / 20 °C

With sodium hydroxide; thionyl chloride; oxalyl dichloride; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1016/j.bmc.2006.05.008

upstream raw materials:

2-amino-4-phosphonobutyric acid

4-nitrobenzyl chloroformate

Downstream raw materials:

methyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoate

ethyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoate

C₁₃H₁₅Cl₂N₂O₇P

C₁₄H₁₇Cl₂N₂O₇P