methyl (R,S)-3-(4-{[N-(dimethylethoxycarbonyl)imino]aminomethyl}phenyl)-4,5-dihydro-5-isoxazoleacetate

Base Information

Chemical Name:methyl (R,S)-3-(4-{[N-(dimethylethoxycarbonyl)imino]aminomethyl}phenyl)-4,5-dihydro-5-isoxazoleacetate
CAS No.:170726-52-0
Molecular Formula:C₁₈H₂₃N₃O₅
Molecular Weight:361.398
Hs Code.:

Synonyms:methyl (R,S)-3-(4-{[N-(dimethylethoxycarbonyl)imino]aminomethyl}phenyl)-4,5-dihydro-5-isoxazoleacetate

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Chemical Property of methyl (R,S)-3-(4-{[N-(dimethylethoxycarbonyl)imino]aminomethyl}phenyl)-4,5-dihydro-5-isoxazoleacetate

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Technology Process of methyl (R,S)-3-(4-{[N-(dimethylethoxycarbonyl)imino]aminomethyl}phenyl)-4,5-dihydro-5-isoxazoleacetate

There total 4 articles about methyl (R,S)-3-(4-{[N-(dimethylethoxycarbonyl)imino]aminomethyl}phenyl)-4,5-dihydro-5-isoxazoleacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 24424-99-5
di-tert-butyl dicarbonate

: methyl (R,S)-3-[4-(aminoiminomethyl)phenyl]-4,5-dihydro-5-isoxazoleacetate hydrochloride

: 170726-52-0
methyl (R,S)-3-(4-{[N-(dimethylethoxycarbonyl)imino]aminomethyl}phenyl)-4,5-dihydro-5-isoxazoleacetate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 22 ℃; for 16h;
DOI:10.1021/jm960799i

Reference yield:

: 52707-54-7,52707-59-2,64847-77-4
4-cyanobenzaldehyde oxime

: 170726-52-0
methyl (R,S)-3-(4-{[N-(dimethylethoxycarbonyl)imino]aminomethyl}phenyl)-4,5-dihydro-5-isoxazoleacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 34 percent / aq. NaOCl / tetrahydrofuran / Ambient temperature

2: 73 percent / HCl / 24 h / Ambient temperature

3: NH₃ / methanol / 14 h / Ambient temperature

4: 75 percent / Et₃N / dimethylformamide / 16 h / 22 °C

With hydrogenchloride; sodium hypochlorite; ammonia; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm960799i

Reference yield:

: 170229-13-7
[3-(4-cyano-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid

: 170726-52-0
methyl (R,S)-3-(4-{[N-(dimethylethoxycarbonyl)imino]aminomethyl}phenyl)-4,5-dihydro-5-isoxazoleacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / HCl / 24 h / Ambient temperature

2: NH₃ / methanol / 14 h / Ambient temperature

3: 75 percent / Et₃N / dimethylformamide / 16 h / 22 °C

With hydrogenchloride; ammonia; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm960799i