(S)-3-(1-(4-(2-(2-(1H-indol-3-yl)-N-methylacetamido)-2-phenylacet-amido)phenyl)-1H-1,2,3-triazol-4-yl)propyl-4-methylbenzenesulfonate

Base Information

Chemical Name:(S)-3-(1-(4-(2-(2-(1H-indol-3-yl)-N-methylacetamido)-2-phenylacet-amido)phenyl)-1H-1,2,3-triazol-4-yl)propyl-4-methylbenzenesulfonate
CAS No.:1361409-75-7
Molecular Formula:C₃₇H₃₆N₆O₅S
Molecular Weight:676.796
Hs Code.:

Synonyms:(S)-3-(1-(4-(2-(2-(1H-indol-3-yl)-N-methylacetamido)-2-phenylacet-amido)phenyl)-1H-1,2,3-triazol-4-yl)propyl-4-methylbenzenesulfonate

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Chemical Property of (S)-3-(1-(4-(2-(2-(1H-indol-3-yl)-N-methylacetamido)-2-phenylacet-amido)phenyl)-1H-1,2,3-triazol-4-yl)propyl-4-methylbenzenesulfonate

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Technology Process of (S)-3-(1-(4-(2-(2-(1H-indol-3-yl)-N-methylacetamido)-2-phenylacet-amido)phenyl)-1H-1,2,3-triazol-4-yl)propyl-4-methylbenzenesulfonate

There total 6 articles about (S)-3-(1-(4-(2-(2-(1H-indol-3-yl)-N-methylacetamido)-2-phenylacet-amido)phenyl)-1H-1,2,3-triazol-4-yl)propyl-4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1145835-70-6
(S)-2-(2-(1H-indol-3-yl)-N-methylacetamido)-N-(4-azidophenyl)-2-phenylacetamide

: 77758-50-0
4-pentynyl-1-tosylate

: 1361409-75-7
(S)-3-(1-(4-(2-(2-(1H-indol-3-yl)-N-methylacetamido)-2-phenylacet-amido)phenyl)-1H-1,2,3-triazol-4-yl)propyl-4-methylbenzenesulfonate

Guidance literature:: 4-pentynyl-1-tosylate; With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In dichloromethane; water; tert-butyl alcohol; at 20 ℃; for 0.25h;

(S)-2-(2-(1H-indol-3-yl)-N-methylacetamido)-N-(4-azidophenyl)-2-phenylacetamide; In dichloromethane; water; tert-butyl alcohol; at 40 ℃; for 24h;
DOI:10.1016/j.bmcl.2011.12.128

Reference yield:

: 1361409-74-6
C₂₀H₂₃N₅O₃

: 1361409-75-7
(S)-3-(1-(4-(2-(2-(1H-indol-3-yl)-N-methylacetamido)-2-phenylacet-amido)phenyl)-1H-1,2,3-triazol-4-yl)propyl-4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

2.1: dmap / dichloromethane; N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 20 °C

3.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / dichloromethane; water; tert-butyl alcohol / 0.25 h / 20 °C

3.2: 24 h / 40 °C

With dmap; copper(ll) sulfate pentahydrate; sodium L-ascorbate; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2011.12.128

Reference yield:

: 1361409-77-9
(S)-tert-butyl 2-(4-azidophenylamino)-2-oxo-1-phenylethyl(methyl)-carbamate

: 1361409-75-7
(S)-3-(1-(4-(2-(2-(1H-indol-3-yl)-N-methylacetamido)-2-phenylacet-amido)phenyl)-1H-1,2,3-triazol-4-yl)propyl-4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap / dichloromethane; N,N-dimethyl-formamide / 0.17 h / 0 °C

1.2: 20 °C

2.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / dichloromethane; water; tert-butyl alcohol / 0.25 h / 20 °C

2.2: 24 h / 40 °C

With dmap; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2011.12.128