(S)-2-(2-(1H-indol-3-yl)-N-methylacetamido)-N-(4-(4-(3-fluoropropyl)-1H-1,2,3-triazol-1-yl)phenyl)-2-phenylacetamide

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Chemical Name:(S)-2-(2-(1H-indol-3-yl)-N-methylacetamido)-N-(4-(4-(3-fluoropropyl)-1H-1,2,3-triazol-1-yl)phenyl)-2-phenylacetamide
CAS No.:1361409-72-4
Molecular Formula:C₃₀H₂₉FN₆O₂
Molecular Weight:524.598
Hs Code.:

Synonyms:(S)-2-(2-(1H-indol-3-yl)-N-methylacetamido)-N-(4-(4-(3-fluoropropyl)-1H-1,2,3-triazol-1-yl)phenyl)-2-phenylacetamide

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Chemical Property of (S)-2-(2-(1H-indol-3-yl)-N-methylacetamido)-N-(4-(4-(3-fluoropropyl)-1H-1,2,3-triazol-1-yl)phenyl)-2-phenylacetamide

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Technology Process of (S)-2-(2-(1H-indol-3-yl)-N-methylacetamido)-N-(4-(4-(3-fluoropropyl)-1H-1,2,3-triazol-1-yl)phenyl)-2-phenylacetamide

There total 7 articles about (S)-2-(2-(1H-indol-3-yl)-N-methylacetamido)-N-(4-(4-(3-fluoropropyl)-1H-1,2,3-triazol-1-yl)phenyl)-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1361409-75-7
(S)-3-(1-(4-(2-(2-(1H-indol-3-yl)-N-methylacetamido)-2-phenylacet-amido)phenyl)-1H-1,2,3-triazol-4-yl)propyl-4-methylbenzenesulfonate

: 1361409-72-4
(S)-2-(2-(1H-indol-3-yl)-N-methylacetamido)-N-(4-(4-(3-fluoropropyl)-1H-1,2,3-triazol-1-yl)phenyl)-2-phenylacetamide

Guidance literature:: With tetrabutyl ammonium fluoride; In hexane; acetonitrile; tert-butyl alcohol; at 70 - 90 ℃; for 2h;
DOI:10.1016/j.bmcl.2011.12.128

Reference yield:

: 1361409-74-6
C₂₀H₂₃N₅O₃

: 1361409-72-4
(S)-2-(2-(1H-indol-3-yl)-N-methylacetamido)-N-(4-(4-(3-fluoropropyl)-1H-1,2,3-triazol-1-yl)phenyl)-2-phenylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

2.1: dmap / dichloromethane; N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 20 °C

3.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / dichloromethane; water; tert-butyl alcohol / 0.25 h / 20 °C

3.2: 24 h / 40 °C

4.1: tetrabutyl ammonium fluoride / hexane; acetonitrile; tert-butyl alcohol / 2 h / 70 - 90 °C

With dmap; copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; sodium L-ascorbate; trifluoroacetic acid; In hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2011.12.128

Reference yield:

: 14860-64-1
4-azidoaniline

: 1361409-72-4
(S)-2-(2-(1H-indol-3-yl)-N-methylacetamido)-N-(4-(4-(3-fluoropropyl)-1H-1,2,3-triazol-1-yl)phenyl)-2-phenylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 0.17 h / 0 °C

1.2: 20 °C

2.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

3.1: dmap / dichloromethane; N,N-dimethyl-formamide / 0.17 h / 0 °C

3.2: 20 °C

4.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / dichloromethane; water; tert-butyl alcohol / 0.25 h / 20 °C

4.2: 24 h / 40 °C

5.1: tetrabutyl ammonium fluoride / hexane; acetonitrile; tert-butyl alcohol / 2 h / 70 - 90 °C

With dmap; copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; benzotriazol-1-ol; sodium L-ascorbate; trifluoroacetic acid; In hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2011.12.128