2-[4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-acetamide

Base Information

• Chemical Name: 2-[4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-acetamide
• CAS No.: 224320-78-9
• Molecular Formula: C₁₅H₁₂ClN₃OS
• Molecular Weight: 317.799

Synonyms:2-[4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-acetamide

Chemical Property of 2-[4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-acetamide

Chemical Property:

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Technology Process of 2-[4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-acetamide

There total 2 articles about 2-[4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-(4-chlorophenyl)-3-cyano-6-methylpyridine-2(1H)-thione (94639-14-2) + Chloroacetamide (79-07-2) → 2-[4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-acetamide (224320-78-9)

Guidance literature:

With sodium methylate; In methanol; for 5h; Heating;

DOI:10.1080/10426509908037022

Reference yield:

methyl 4-chlorocinnamate (7560-44-3,20754-21-6,20754-24-9) → 2-[4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-acetamide (224320-78-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / Et₃N / methanol / 5 h / Heating

2: 78 percent / NaOMe / methanol / 5 h / Heating

With sodium methylate; triethylamine; In methanol; 1: cyclocondensation / 2: Alkylation;

DOI:10.1080/10426509908037022

Reference yield: 87.0%

2-[4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-acetamide (224320-78-9) → 3-amino-4-(4-chloro-phenyl)-6-methyl-thieno[2,3-b]pyridine-2-carboxylic acid amide

Guidance literature:

With potassium hydroxide; In ethanol; for 5h; Heating;

DOI:10.1080/10426509908037022

upstream raw materials:

4-(4-chlorophenyl)-3-cyano-6-methylpyridine-2(1H)-thione

Chloroacetamide

methyl 4-chlorocinnamate

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