phosphoric acid 5-(4-bromobenzyl)-7-(3,5-dichlorophenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazol-3-yl ester diethyl ester

Base Information

Chemical Name:phosphoric acid 5-(4-bromobenzyl)-7-(3,5-dichlorophenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazol-3-yl ester diethyl ester
CAS No.:397329-89-4
Molecular Formula:C₂₃H₂₃BrCl₂N₃O₅P
Molecular Weight:603.236
Hs Code.:

Synonyms:phosphoric acid 5-(4-bromobenzyl)-7-(3,5-dichlorophenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazol-3-yl ester diethyl ester

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Chemical Property of phosphoric acid 5-(4-bromobenzyl)-7-(3,5-dichlorophenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazol-3-yl ester diethyl ester

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Technology Process of phosphoric acid 5-(4-bromobenzyl)-7-(3,5-dichlorophenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazol-3-yl ester diethyl ester

There total 13 articles about phosphoric acid 5-(4-bromobenzyl)-7-(3,5-dichlorophenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazol-3-yl ester diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 814-49-3
diethyl chlorophosphate

: 397329-88-3
3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1,6-dehydroimidazo[1,2-a]imidazole-2,5-dione

: 397329-89-4
phosphoric acid 5-(4-bromobenzyl)-7-(3,5-dichlorophenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazol-3-yl ester diethyl ester

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; at -20 ℃;
DOI:10.1016/S0040-4039(03)01535-1

Reference yield:

: 302840-67-1
(2R)-2-amino-3-(4-bromophenyl)-N-(3,5-dichlorophenyl)-2-methyl-propionamide

: 397329-89-4
phosphoric acid 5-(4-bromobenzyl)-7-(3,5-dichlorophenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazol-3-yl ester diethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: tBuCOCl / tetrahydrofuran / 0 - 10 °C

2: TsOH*H₂O / methanol / 50 °C

3: tetrahydrofuran / 20 - 35 °C

4: 91 percent / CuCl; iPr₂NEt; Celite / toluene; acetonitrile / 0.5 h / 80 °C

5: LHMDS / tetrahydrofuran / -10 °C

With Celite; pivaloyl chloride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; copper(l) chloride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; toluene; acetonitrile;
DOI:10.1016/j.tetlet.2004.11.065

Reference yield:

: 302840-67-1
(2R)-2-amino-3-(4-bromophenyl)-N-(3,5-dichlorophenyl)-2-methyl-propionamide

: 397329-89-4
phosphoric acid 5-(4-bromobenzyl)-7-(3,5-dichlorophenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazol-3-yl ester diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 2.5 h / 20 °C

2: 81 percent / Ph₃P / CCl₄; triethylamine / 12 h / 20 °C

3: 91 percent / Me₃Al; Ph₃PO / toluene / 25 °C

4: 92 percent / KN(TMS)2 / tetrahydrofuran / -20 °C

With trimethylaluminum; potassium hexamethylsilazane; triphenylphosphine; Triphenylphosphine oxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; triethylamine; toluene;
DOI:10.1016/S0040-4039(03)01535-1