(5R)-5-[(4-bromophenyl)methyl]-7-(3,5-dichlorophenyl)-5-methyl-2H-imidazo[1,2-a]imidazole-3,6-dione

Base Information

Chemical Name:(5R)-5-[(4-bromophenyl)methyl]-7-(3,5-dichlorophenyl)-5-methyl-2H-imidazo[1,2-a]imidazole-3,6-dione
CAS No.:397329-88-3
Molecular Formula:C19H14BrCl2N3O2
Molecular Weight:467.149
Hs Code.:
DSSTox Substance ID:DTXSID50458198
Nikkaji Number:J1.928.824B
Wikidata:Q82281380

Synonyms:397329-88-3;(5R)-5-[(4-bromophenyl)methyl]-7-(3,5-dichlorophenyl)-5-methyl-2H-imidazo[1,2-a]imidazole-3,6-dione;SCHEMBL7513054;DTXSID50458198;IPUSXBRIHIMPOO-LJQANCHMSA-N;(3R)-1-(3,5-Dichlorophenyl)-3alpha-methyl-3-(4-bromobenzyl)-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazole-2,5-dione;(R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1,6-dihydroimidazo[1,2-alpha]imidazole-2,5-dione

Suppliers and Price of (5R)-5-[(4-bromophenyl)methyl]-7-(3,5-dichlorophenyl)-5-methyl-2H-imidazo[1,2-a]imidazole-3,6-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of (5R)-5-[(4-bromophenyl)methyl]-7-(3,5-dichlorophenyl)-5-methyl-2H-imidazo[1,2-a]imidazole-3,6-dione

Chemical Property:

XLogP3:4.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:464.96464
Heavy Atom Count:27
Complexity:657

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(C(=O)N(C2=NCC(=O)N21)C3=CC(=CC(=C3)Cl)Cl)CC4=CC=C(C=C4)Br
Isomeric SMILES:C[C@]1(C(=O)N(C2=NCC(=O)N21)C3=CC(=CC(=C3)Cl)Cl)CC4=CC=C(C=C4)Br

Technology Process of (5R)-5-[(4-bromophenyl)methyl]-7-(3,5-dichlorophenyl)-5-methyl-2H-imidazo[1,2-a]imidazole-3,6-dione

There total 10 articles about (5R)-5-[(4-bromophenyl)methyl]-7-(3,5-dichlorophenyl)-5-methyl-2H-imidazo[1,2-a]imidazole-3,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 397329-87-2
[4-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-4-methyl-5-oxoimidazolidin-2-ylideneamino]acetic acid ethyl ester

: 397329-88-3
3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1,6-dehydroimidazo[1,2-a]imidazole-2,5-dione

Guidance literature:: With trimethylaluminum; Triphenylphosphine oxide; In toluene; at 25 ℃;
DOI:10.1016/S0040-4039(03)01535-1

Reference yield:

: 302840-67-1
(2R)-2-amino-3-(4-bromophenyl)-N-(3,5-dichlorophenyl)-2-methyl-propionamide

: 397329-88-3
3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1,6-dehydroimidazo[1,2-a]imidazole-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1: tBuCOCl / tetrahydrofuran / 0 - 10 °C

2: TsOH*H₂O / methanol / 50 °C

3: tetrahydrofuran / 20 - 35 °C

4: 91 percent / CuCl; iPr₂NEt; Celite / toluene; acetonitrile / 0.5 h / 80 °C

With Celite; pivaloyl chloride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; copper(l) chloride; In tetrahydrofuran; methanol; toluene; acetonitrile;
DOI:10.1016/j.tetlet.2004.11.065