302840-67-1

Upstream product

• 321724-17-8 (2S,5R)-2-tert-butyl-3-(3,5-dichlorophenyl)-5-methyl-1-trifluoroacetyl-imidazolidin-4-one 
• 341027-25-6 (2R,5R)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trichloroacetyl)-imidazolidin-4-one 
• 626-43-7 3,5-Dichloroaniline 
• 341027-24-5 (2S,5R)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methylimidazolidin-4-one 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 302840-63-7 (1R)-[1-(3,5-dichloro-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester 
• 648422-57-5 (2S,5R)-2-tert-butyl-3-(3,5-dichlorophenyl)-5-methyl-imidazolidin-4-one 
• 302840-64-8 (2R)-2-amino-N-(3,5-dichlorophenyl)-propionamide 
• 341027-26-7 (2R,5R)-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trichloroacetyl)-imidazolidin-4-one 
• 648422-58-6 (2R,5R)-5-(4-bromo-benzyl)-2-tert-butyl-3-(3,5-dichlorophenyl)-5-methyl-1-trifluoroacetyl-imidazolin-4-one 

Downstream Products

• 213208-73-2 (5R)-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-5-methyl-1H-imidazole-2,4(3H,5H)-dione 
• 835917-10-7 {[2-(4-bromo-phenyl)-1-(3,5-dichloro-phenylcarbamoyl)-1-methyl-ethylcarbamoyl]-methyl}-carbamic acid tert-butyl ester 
• 397329-88-3 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1,6-dehydroimidazo[1,2-a]imidazole-2,5-dione 
• 321656-73-9 (R)-3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1H-imidazo[1,2-α]imidazol-2-one 
• 397329-89-4 phosphoric acid 5-(4-bromobenzyl)-7-(3,5-dichlorophenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazol-3-yl ester diethyl ester 
• 835917-12-9 2-(2-amino-acetylamino)-3-(4-bromo-phenyl)-N-(3,5-dichloro-phenyl)-2-methyl-propionamide 
• 835917-14-1 3-(4-bromo-phenyl)-N-(3,5-dichloro-phenyl)-2-methyl-2-(5-oxo-2-thioxo-imidazolidin-1-yl)-propionamide 
• 321656-72-8 (R)-3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1-hydroimidazo[1,2-a]imidazol-2-one 
• 875210-73-4 (R)-2-[(4',4'-dimethoxyethyl)aminocarbonyl]amino-2-(4-bromobenzyl)-N-(3,5-dichlorophenyl)-propionamide 
• 397329-87-2 [4-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-4-methyl-5-oxoimidazolidin-2-ylideneamino]acetic acid ethyl ester 
• 397329-91-8 [4-(4-bromo-benzyl)-1-(3,5-dichloro-phenyl)-4-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-ylamino]-acetic acid 
• 397329-86-1 (R){3-[2-(4-Bromophenyl)-1-(3,5-dichlorophenylcarbamoyl)-1-methyl-ethyl]-ureido}-acetic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis of 6,7-Dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides

Disclosed is an improved multi-step process for preparing a compound of Formula I: wherein R1 to R3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins

Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides

Disclosed is a multi-step process for preparing a compound of Formula I: wherein R1 to R3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a res

A practical synthesis of LFA-1 inhibitors utilizing CuCl-promoted intramolecular cyclization of thiohydantoins

An efficient and chromatography-free approach for synthesis of a new class of LFA-1 inhibitors was developed. A copper(I) chloride-promoted intramolecular cyclization of thiohydantoins 7a-b serves as a key step to highly functionalized bicyclic guanidines

A practical synthesis of highly functionalized fused 1,6-dihydroimidazo-[1, 2-a]imidazole-2,5-diones, key intermediates for LFA-1 inhibitors

An alternative and chromatography-free approach for synthesis of a new class of LFA-1 inhibitors was developed. A key feature of this process involved a transformation of thioureas 14 to acyclic guanidine derivatives 9 followed by intramolecular cyclizati

Practical synthesis of a cell adhesion inhibitor by self-regeneration of stereocenters

An efficient enantiospecific synthesis of the cell adhesion inhibitor BIRT-377 by self-regeneration of stereocenters has been achieved in 38% overall yield in eight steps. The key transformations involve the stereoselective formation of the trans imidazol

An improved synthesis of N-aryl-hydantoin LFA-1 antagonists via the enantiospecific alkylation of an isobutyraldehyde-derived imidazolidinone template

An improved and cost-effective process for the synthesis of N-aryl-hydantoin LFA-1 antagonists is described. Key transformations include the synthesis and stereospecific alkylation of the trans-isobutyraldehyde-derived template 4, and the one-pot hydrolys

Self-regeneration of stereocenters: A practical enantiospecific synthesis of LFA-1 antagonist BIRT-377

An efficient enantiospecific synthesis of the LFA-1 antagonist BIRT-377 has been achieved in 43percent overall yield in eight steps. The key transformations involve the stereospecific formation of the trans imidazolidinone 7, subsequent alkylation, and th