N-(1-benzotriazolecarbonyl)-L-phenylalanine cyclohexylamide

Base Information

• Chemical Name: N-(1-benzotriazolecarbonyl)-L-phenylalanine cyclohexylamide
• CAS No.: 845786-67-6
• Molecular Formula: C₂₂H₂₅N₅O₂
• Molecular Weight: 391.473
• Mol file: 845786-67-6.mol

Synonyms:N-(1-benzotriazolecarbonyl)-L-phenylalanine cyclohexylamide

Chemical Property of N-(1-benzotriazolecarbonyl)-L-phenylalanine cyclohexylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-benzotriazolecarbonyl)-L-phenylalanine cyclohexylamide

There total 5 articles about N-(1-benzotriazolecarbonyl)-L-phenylalanine cyclohexylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexylamine (108-91-8,157973-60-9) + (S)-2-[(Benzotriazole-1-carbonyl)-amino]-3-phenyl-propionyl chloride (81917-73-9) → N-(1-benzotriazolecarbonyl)-L-phenylalanine cyclohexylamide (845786-67-6)

Guidance literature:

With triethylamine; In toluene; at 20 ℃; for 24h;

DOI:10.1021/jm040869i

Reference yield:

N-(1-Benzotriazolylcarbonyl)-L-phenylalanin (81917-69-3) → N-(1-benzotriazolecarbonyl)-L-phenylalanine cyclohexylamide (845786-67-6)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 1 h / Heating

2: triethylamine / toluene / 24 h / 20 °C

With thionyl chloride; triethylamine; In toluene;

DOI:10.3390/11110837

Reference yield:

1-benzotriazolecarboxylic acid chloride (65095-13-8) → N-(1-benzotriazolecarbonyl)-L-phenylalanine cyclohexylamide (845786-67-6)

Guidance literature:

Multi-step reaction with 3 steps

1: dioxane / 24 h / 20 °C

2: SOCl₂ / 1 h / Heating

3: triethylamine / toluene / 24 h / 20 °C

With thionyl chloride; triethylamine; In 1,4-dioxane; toluene;

DOI:10.3390/11110837

upstream raw materials:

cyclohexylamine

(S)-2-[(Benzotriazole-1-carbonyl)-amino]-3-phenyl-propionyl chloride

L-phenylalanine

N-(1-Benzotriazolylcarbonyl)-L-phenylalanin

Refernces

• 1、 Opa?i?, Ninoslav,Barbari?, Monika,Zorc, Branka,Cetina, Mario,Nagl, Ante,Frkovi?, Danijel,Kralj, Marijeta,Paveli?, Kre?imir,Balzarini, Jan,Andrei, Graciela,Snoeck, Robert,De Clercq, Erik,Rai?-Mali?, Silvana,Mintas, Mladen. "The novel L- and D-amino acid derivatives of hydroxyurea and hydantoins: Synthesis, X-ray crystal structure study, and cytostatic and antiviral activity evaluations". . p. 475 - 482. Retrieved 2007/10/03.