benzyl 4-((1R,2R)-2-(2-(2-(2-(dimethylamino)-2-oxoethyl)-3,5-difluorophenoxy)ethyl)cyclopropyl)piperidine-1-carboxylate

Base Information

Chemical Name:benzyl 4-((1R,2R)-2-(2-(2-(2-(dimethylamino)-2-oxoethyl)-3,5-difluorophenoxy)ethyl)cyclopropyl)piperidine-1-carboxylate
CAS No.:1588945-08-7
Molecular Formula:C₂₈H₃₄F₂N₂O₄
Molecular Weight:500.586
Hs Code.:

Synonyms:benzyl 4-((1R,2R)-2-(2-(2-(2-(dimethylamino)-2-oxoethyl)-3,5-difluorophenoxy)ethyl)cyclopropyl)piperidine-1-carboxylate

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Chemical Property of benzyl 4-((1R,2R)-2-(2-(2-(2-(dimethylamino)-2-oxoethyl)-3,5-difluorophenoxy)ethyl)cyclopropyl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of benzyl 4-((1R,2R)-2-(2-(2-(2-(dimethylamino)-2-oxoethyl)-3,5-difluorophenoxy)ethyl)cyclopropyl)piperidine-1-carboxylate

There total 3 articles about benzyl 4-((1R,2R)-2-(2-(2-(2-(dimethylamino)-2-oxoethyl)-3,5-difluorophenoxy)ethyl)cyclopropyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1588944-69-7
benzyl 4-((1R,2R)-2-(2-hydroxyethyl)cyclopropyl)piperidine-1-carboxylate

: 1588944-86-8
N,N-dimethyl-2-(2,4,6-trifluorophenyl)acetamide

: 1588945-08-7
benzyl 4-((1R,2R)-2-(2-(2-(2-(dimethylamino)-2-oxoethyl)-3,5-difluorophenoxy)ethyl)cyclopropyl)piperidine-1-carboxylate

Guidance literature:: With sodium t-butanolate; In tetrahydrofuran; at 20 - 120 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 209991-63-9
2,4,6-trifluorophenylacetic acid

: 1588945-08-7
benzyl 4-((1R,2R)-2-(2-(2-(2-(dimethylamino)-2-oxoethyl)-3,5-difluorophenoxy)ethyl)cyclopropyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 20 °C

2: sodium t-butanolate / tetrahydrofuran / 1 h / 20 - 120 °C / Inert atmosphere; Microwave irradiation

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium t-butanolate; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1588944-68-6
benzyl 4-((1R,2R)-2-vinylcyclopropyl)piperidine-1-carboxylate

: 1588945-08-7
benzyl 4-((1R,2R)-2-(2-(2-(2-(dimethylamino)-2-oxoethyl)-3,5-difluorophenoxy)ethyl)cyclopropyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 - 20 °C

1.2: 1 h / 20 °C

2.1: sodium t-butanolate / tetrahydrofuran / 1 h / 20 - 120 °C / Inert atmosphere; Microwave irradiation

With dimethylsulfide borane complex; sodium t-butanolate; In tetrahydrofuran;