2-(2,4-difluoro-6-(2-((1R,2R)-2-(piperidin-4-yl)cyclopropyl)ethoxy)phenyl)-N,N-dimethylacetamide

Base Information

Chemical Name:2-(2,4-difluoro-6-(2-((1R,2R)-2-(piperidin-4-yl)cyclopropyl)ethoxy)phenyl)-N,N-dimethylacetamide
CAS No.:1588945-09-8
Molecular Formula:C₂₀H₂₈F₂N₂O₂
Molecular Weight:366.451
Hs Code.:

Synonyms:2-(2,4-difluoro-6-(2-((1R,2R)-2-(piperidin-4-yl)cyclopropyl)ethoxy)phenyl)-N,N-dimethylacetamide

Suppliers and Price of 2-(2,4-difluoro-6-(2-((1R,2R)-2-(piperidin-4-yl)cyclopropyl)ethoxy)phenyl)-N,N-dimethylacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(2,4-difluoro-6-(2-((1R,2R)-2-(piperidin-4-yl)cyclopropyl)ethoxy)phenyl)-N,N-dimethylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(2,4-difluoro-6-(2-((1R,2R)-2-(piperidin-4-yl)cyclopropyl)ethoxy)phenyl)-N,N-dimethylacetamide

There total 4 articles about 2-(2,4-difluoro-6-(2-((1R,2R)-2-(piperidin-4-yl)cyclopropyl)ethoxy)phenyl)-N,N-dimethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1588945-08-7
benzyl 4-((1R,2R)-2-(2-(2-(2-(dimethylamino)-2-oxoethyl)-3,5-difluorophenoxy)ethyl)cyclopropyl)piperidine-1-carboxylate

: 1588945-09-8
2-(2,4-difluoro-6-(2-((1R,2R)-2-(piperidin-4-yl)cyclopropyl)ethoxy)phenyl)-N,N-dimethylacetamide

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 1h; under 760.051 Torr;

Reference yield:

: 209991-63-9
2,4,6-trifluorophenylacetic acid

: 1588945-09-8
2-(2,4-difluoro-6-(2-((1R,2R)-2-(piperidin-4-yl)cyclopropyl)ethoxy)phenyl)-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 20 °C

2: sodium t-butanolate / tetrahydrofuran / 1 h / 20 - 120 °C / Inert atmosphere; Microwave irradiation

3: hydrogen; palladium on activated charcoal / methanol / 1 h / 20 °C / 760.05 Torr

With palladium on activated charcoal; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium t-butanolate; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1588944-68-6
benzyl 4-((1R,2R)-2-vinylcyclopropyl)piperidine-1-carboxylate

: 1588945-09-8
2-(2,4-difluoro-6-(2-((1R,2R)-2-(piperidin-4-yl)cyclopropyl)ethoxy)phenyl)-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 - 20 °C

1.2: 1 h / 20 °C

2.1: sodium t-butanolate / tetrahydrofuran / 1 h / 20 - 120 °C / Inert atmosphere; Microwave irradiation

3.1: hydrogen; palladium on activated charcoal / methanol / 1 h / 20 °C / 760.05 Torr

With dimethylsulfide borane complex; palladium on activated charcoal; hydrogen; sodium t-butanolate; In tetrahydrofuran; methanol;