3-((4S,trans)-4,5-dihydro-4-methyl-2-phenyloxazol-5-yl)-heptadecan-3-one-16-ethylenacetal

Base Information

• Chemical Name: 3-((4S,trans)-4,5-dihydro-4-methyl-2-phenyloxazol-5-yl)-heptadecan-3-one-16-ethylenacetal
• CAS No.: 503560-05-2
• Molecular Formula: C₂₉H₄₅NO₄
• Molecular Weight: 471.681
• Mol file: 503560-05-2.mol

Synonyms:3-((4S,trans)-4,5-dihydro-4-methyl-2-phenyloxazol-5-yl)-heptadecan-3-one-16-ethylenacetal

Chemical Property of 3-((4S,trans)-4,5-dihydro-4-methyl-2-phenyloxazol-5-yl)-heptadecan-3-one-16-ethylenacetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((4S,trans)-4,5-dihydro-4-methyl-2-phenyloxazol-5-yl)-heptadecan-3-one-16-ethylenacetal

There total 15 articles about 3-((4S,trans)-4,5-dihydro-4-methyl-2-phenyloxazol-5-yl)-heptadecan-3-one-16-ethylenacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-(12-bromododecyl)-2-methyl-1,3-dioxolane (118399-90-9) + 3-((4S,trans)-4,5-dihydro-4-methyl-2-phenyloxazol-5-yl)-N-methoxy-N-methyl propionamide (503560-09-6) → 3-((4S,trans)-4,5-dihydro-4-methyl-2-phenyloxazol-5-yl)-heptadecan-3-one-16-ethylenacetal (503560-05-2)

Guidance literature:

2-(12-bromododecyl)-2-methyl-1,3-dioxolane; With magnesium; ethylene dibromide; In tetrahydrofuran;

3-((4S,trans)-4,5-dihydro-4-methyl-2-phenyloxazol-5-yl)-N-methoxy-N-methyl propionamide; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1016/S0957-4166(02)00794-2

Reference yield:

2-(2-bromoethyl)-2-methyl-1,3-dioxolane (37865-96-6) → 3-((4S,trans)-4,5-dihydro-4-methyl-2-phenyloxazol-5-yl)-heptadecan-3-one-16-ethylenacetal (503560-05-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Mg

1.2: 52 percent / dilithium tetrachlorocuprate / tetrahydrofuran / 2 h

2.1: Mg; 1,2-dibromoethane / tetrahydrofuran

2.2: 70 percent / tetrahydrofuran / 2 h / 0 °C

With magnesium; ethylene dibromide; In tetrahydrofuran;

DOI:10.1016/S0957-4166(02)00794-2

Reference yield:

1,10-dibromodecane (4101-68-2) → 3-((4S,trans)-4,5-dihydro-4-methyl-2-phenyloxazol-5-yl)-heptadecan-3-one-16-ethylenacetal (503560-05-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Mg

1.2: 52 percent / dilithium tetrachlorocuprate / tetrahydrofuran / 2 h

2.1: Mg; 1,2-dibromoethane / tetrahydrofuran

2.2: 70 percent / tetrahydrofuran / 2 h / 0 °C

With magnesium; ethylene dibromide; In tetrahydrofuran;

DOI:10.1016/S0957-4166(02)00794-2

upstream raw materials:

2-(12-bromododecyl)-2-methyl-1,3-dioxolane

3-((4S,trans)-4,5-dihydro-4-methyl-2-phenyloxazol-5-yl)-N-methoxy-N-methyl propionamide

2-(2-bromoethyl)-2-methyl-1,3-dioxolane

1,10-dibromodecane