Technology Process of 3-((4S,trans)-4,5-dihydro-4-methyl-2-phenyloxazol-5-yl)-N-methoxy-N-methyl propionamide
There total 12 articles about 3-((4S,trans)-4,5-dihydro-4-methyl-2-phenyloxazol-5-yl)-N-methoxy-N-methyl propionamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride;
In
methanol; benzene;
for 1h;
Heating;
DOI:10.1016/S0957-4166(02)00794-2
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: O3 / methanol / -78 °C
2.1: LiCl; DBU / acetonitrile / 1 h
2.2: 2.03 g / acetonitrile / 2 h
3.1: 82.4 percent / CuBr; Red-Al; 2-butanol / tetrahydrofuran / 4 h / -20 °C
4.1: aq. LiOH / tetrahydrofuran / 2 h
5.1: 491 mg / Et3N; DCC; HOBt / CH2Cl2 / 12 h
6.1: 94 percent / TBAF / tetrahydrofuran / 1 h / 20 °C
7.1: 90 percent / PPh3; imidazole; I2 / acetonitrile; diethyl ether / 4 h / 20 °C
8.1: 87.5 percent / AIBN; Bu3SnH / benzene; methanol / 1 h / Heating
With
1H-imidazole; lithium hydroxide; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; iodine; tri-n-butyl-tin hydride; benzotriazol-1-ol; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; iso-butanol; lithium chloride; copper(I) bromide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile; benzene;
DOI:10.1016/S0957-4166(02)00794-2
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: 96 percent / tetrahydrofuran / 1 h / -78 °C
2.1: 99 percent / pyridine / CH2Cl2 / 12 h
3.1: 75 percent / K2CO3; Pd(PPh3)4 / acetonitrile / 24 h / Heating
4.1: O3 / methanol / -78 °C
5.1: LiCl; DBU / acetonitrile / 1 h
5.2: 2.03 g / acetonitrile / 2 h
6.1: 82.4 percent / CuBr; Red-Al; 2-butanol / tetrahydrofuran / 4 h / -20 °C
7.1: aq. LiOH / tetrahydrofuran / 2 h
8.1: 491 mg / Et3N; DCC; HOBt / CH2Cl2 / 12 h
9.1: 94 percent / TBAF / tetrahydrofuran / 1 h / 20 °C
10.1: 90 percent / PPh3; imidazole; I2 / acetonitrile; diethyl ether / 4 h / 20 °C
11.1: 87.5 percent / AIBN; Bu3SnH / benzene; methanol / 1 h / Heating
With
pyridine; 1H-imidazole; lithium hydroxide; tetrakis(triphenylphosphine) palladium(0); 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; iodine; tri-n-butyl-tin hydride; potassium carbonate; benzotriazol-1-ol; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; iso-butanol; lithium chloride; copper(I) bromide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile; benzene;
DOI:10.1016/S0957-4166(02)00794-2
