Technology Process of 3-{[(2R)-4-benzylmorpholin-2-yl]methyl}-7-chloro-5-(trifluoromethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine
There total 5 articles about 3-{[(2R)-4-benzylmorpholin-2-yl]methyl}-7-chloro-5-(trifluoromethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N4-{[(2S)-4-Benzylmorpholin-2-yl]methyl}-6-chloro-2-(trifluoromethyl)pyrimidine-4,5-diamine;
With
hydrogenchloride; sodium nitrite;
In
2-methyltetrahydrofuran; water;
at 20 ℃;
for 1.16667h;
With
sodium carbonate;
In
2-methyltetrahydrofuran; water;
pH=9 - 10;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: trifluoroacetic acid / 15 h / 20 °C
1.2: 25 °C
2.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate; phosphoric acid / 20 - 45 °C / Inert atmosphere
3.1: acetic acid; iron / 1.25 h / 50 °C
4.1: sodium carbonate / acetonitrile / 36 h / 80 °C
5.1: hydrogenchloride; sodium nitrite / water; 2-methyltetrahydrofuran / 1.17 h / 20 °C
5.2: pH 9 - 10
With
hydrogenchloride; phosphoric acid; iron; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium nitrite; trichlorophosphate;
In
2-methyltetrahydrofuran; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: acetic acid; iron / 1.25 h / 50 °C
2.1: sodium carbonate / acetonitrile / 36 h / 80 °C
3.1: hydrogenchloride; sodium nitrite / water; 2-methyltetrahydrofuran / 1.17 h / 20 °C
3.2: pH 9 - 10
With
hydrogenchloride; iron; sodium carbonate; acetic acid; sodium nitrite;
In
2-methyltetrahydrofuran; water; acetonitrile;