3-{[(2R)-4-benzylmorpholin-2-yl]methyl}-5-(trifluoromethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine

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Chemical Name:3-{[(2R)-4-benzylmorpholin-2-yl]methyl}-5-(trifluoromethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine
CAS No.:1305115-74-5
Molecular Formula:C₁₇H₁₈F₃N₇O
Molecular Weight:393.371
Hs Code.:

Synonyms:3-{[(2R)-4-benzylmorpholin-2-yl]methyl}-5-(trifluoromethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine

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Chemical Property of 3-{[(2R)-4-benzylmorpholin-2-yl]methyl}-5-(trifluoromethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine

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Technology Process of 3-{[(2R)-4-benzylmorpholin-2-yl]methyl}-5-(trifluoromethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine

There total 6 articles about 3-{[(2R)-4-benzylmorpholin-2-yl]methyl}-5-(trifluoromethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1305117-37-6
3-{[(2R)-4-benzylmorpholin-2-yl]methyl}-7-chloro-5-(trifluoromethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

: 1305115-74-5
3-{[(2R)-4-benzylmorpholin-2-yl]methyl}-5-(trifluoromethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine

Guidance literature:: With ammonium hydroxide; In 2-methyltetrahydrofuran; at 80 ℃; Sealed tube;

Reference yield:

: 672-47-9
2-trifluoromethyl-4,6-dihydroxypyrimidine

: 1305115-74-5
3-{[(2R)-4-benzylmorpholin-2-yl]methyl}-5-(trifluoromethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: trifluoroacetic acid / 15 h / 20 °C

1.2: 25 °C

2.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate; phosphoric acid / 20 - 45 °C / Inert atmosphere

3.1: acetic acid; iron / 1.25 h / 50 °C

4.1: sodium carbonate / acetonitrile / 36 h / 80 °C

5.1: hydrogenchloride; sodium nitrite / water; 2-methyltetrahydrofuran / 1.17 h / 20 °C

5.2: pH 9 - 10

6.1: ammonium hydroxide / 2-methyltetrahydrofuran / 80 °C / Sealed tube

With hydrogenchloride; ammonium hydroxide; phosphoric acid; iron; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium nitrite; trichlorophosphate; In 2-methyltetrahydrofuran; water; acetonitrile;

Reference yield:

: 715-46-8
4,6-dichloro-5-nitro-2-trifluoro-methyl-pyrimidine

: 1305115-74-5
3-{[(2R)-4-benzylmorpholin-2-yl]methyl}-5-(trifluoromethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid; iron / 1.25 h / 50 °C

2.1: sodium carbonate / acetonitrile / 36 h / 80 °C

3.1: hydrogenchloride; sodium nitrite / water; 2-methyltetrahydrofuran / 1.17 h / 20 °C

3.2: pH 9 - 10

4.1: ammonium hydroxide / 2-methyltetrahydrofuran / 80 °C / Sealed tube

With hydrogenchloride; ammonium hydroxide; iron; sodium carbonate; acetic acid; sodium nitrite; In 2-methyltetrahydrofuran; water; acetonitrile;