Benzyloxycarbonylamino-acetic acid 3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-1-phenyl-allyl ester

Base Information

Chemical Name:Benzyloxycarbonylamino-acetic acid 3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-1-phenyl-allyl ester
CAS No.:216435-66-4
Molecular Formula:C₂₃H₂₅F₂NO₇
Molecular Weight:465.451
Hs Code.:

Synonyms:Benzyloxycarbonylamino-acetic acid 3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-1-phenyl-allyl ester

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Chemical Property of Benzyloxycarbonylamino-acetic acid 3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-1-phenyl-allyl ester

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Technology Process of Benzyloxycarbonylamino-acetic acid 3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-1-phenyl-allyl ester

There total 1 articles about Benzyloxycarbonylamino-acetic acid 3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-1-phenyl-allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 170941-69-2
3,3-Difluoro-2-(2-methoxy-ethoxymethoxy)-1-phenyl-prop-2-en-1-ol

: 216435-66-4
Benzyloxycarbonylamino-acetic acid 3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-1-phenyl-allyl ester

Guidance literature:: With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 0 ℃; for 0.0833333h;
DOI:10.1021/jo981119h

Reference yield:

: 216435-66-4
Benzyloxycarbonylamino-acetic acid 3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-1-phenyl-allyl ester

: 2-Benzyloxycarbonylamino-3,3-difluoro-4-oxo-5-phenyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA, 2.) ZnCl₂ / 1) THF, hexane, -78 deg C, 5 min; 2) THF, hexane, -78 deg C --> rt, 1 h

2: EDC, DMAP / CH₂Cl₂ / 0 - 20 °C

3: 72 percent / thionyl chloride / CHCl₃; methanol / 0 - 20 °C

With dmap; thionyl chloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; zinc(II) chloride; lithium diisopropyl amide; In methanol; dichloromethane; chloroform;
DOI:10.1021/jo981119h

Reference yield:

: 216435-66-4
Benzyloxycarbonylamino-acetic acid 3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-1-phenyl-allyl ester

: (Z)-2-Benzyloxycarbonylamino-3,3-difluoro-4-(2-methoxy-ethoxymethoxy)-5-phenyl-pent-4-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA, 2.) ZnCl₂ / 1) THF, hexane, -78 deg C, 5 min; 2) THF, hexane, -78 deg C --> rt, 1 h

2: EDC, DMAP / CH₂Cl₂ / 0 - 20 °C

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; zinc(II) chloride; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jo981119h