6-[4-(chloromethyl)phenyl]-N'-{2-cyano-9-[2-(dimethylamino) ethyl]-9H-purin-6-yl}-N'-cyclohexyl-2-pyridinecarbohydrazide

Base Information

Chemical Name:6-[4-(chloromethyl)phenyl]-N'-{2-cyano-9-[2-(dimethylamino) ethyl]-9H-purin-6-yl}-N'-cyclohexyl-2-pyridinecarbohydrazide
CAS No.:1055927-70-2
Molecular Formula:C₂₉H₃₂ClN₉O
Molecular Weight:558.086
Hs Code.:

Synonyms:6-[4-(chloromethyl)phenyl]-N'-{2-cyano-9-[2-(dimethylamino) ethyl]-9H-purin-6-yl}-N'-cyclohexyl-2-pyridinecarbohydrazide

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Chemical Property of 6-[4-(chloromethyl)phenyl]-N'-{2-cyano-9-[2-(dimethylamino) ethyl]-9H-purin-6-yl}-N'-cyclohexyl-2-pyridinecarbohydrazide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6-[4-(chloromethyl)phenyl]-N'-{2-cyano-9-[2-(dimethylamino) ethyl]-9H-purin-6-yl}-N'-cyclohexyl-2-pyridinecarbohydrazide

There total 8 articles about 6-[4-(chloromethyl)phenyl]-N'-{2-cyano-9-[2-(dimethylamino) ethyl]-9H-purin-6-yl}-N'-cyclohexyl-2-pyridinecarbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1055927-49-5
6-[4-(chloromethyl)phenyl]-2-pyridinecarbonyl chloride

: 1055927-66-6
6-(1-cyclohexylhydrazino)-9-[2-(dimethylamino)ethyl]-9H-purine-2-carbonitrile

: 1055927-70-2
6-[4-(chloromethyl)phenyl]-N'-{2-cyano-9-[2-(dimethylamino) ethyl]-9H-purin-6-yl}-N'-cyclohexyl-2-pyridinecarbohydrazide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

Reference yield:

: 21190-87-4
6-bromo-pyridine-2-carboxylic acid

: 1055927-70-2
6-[4-(chloromethyl)phenyl]-N'-{2-cyano-9-[2-(dimethylamino) ethyl]-9H-purin-6-yl}-N'-cyclohexyl-2-pyridinecarbohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.25 h / 20 °C

1.2: 20 h / 95 °C / Heating / reflux

1.3: pH 3

2.1: thionyl chloride / 2 h / Heating / reflux

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

With thionyl chloride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane;

Reference yield:

: 1055927-13-3
1,1-dimethylethyl 2-[2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl]-2-cyclohexylhydrazinecarboxylate

: 1055927-70-2
6-[4-(chloromethyl)phenyl]-N'-{2-cyano-9-[2-(dimethylamino) ethyl]-9H-purin-6-yl}-N'-cyclohexyl-2-pyridinecarbohydrazide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,1'-bis-(diphenylphosphino)ferrocene; zinc / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 3 h / 150 °C

2.1: Dowex 50x2-200 resin / ethanol / 26 h / 20 °C / Heating / reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h

3.2: 20 - 60 °C

4.1: toluene-4-sulfonic acid / acetonitrile / 20 °C

4.2: 0 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

With 1,1'-bis-(diphenylphosphino)ferrocene; Dowex 50x2-200 resin; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; ethanol; ISOPROPYLAMIDE; N,N-dimethyl-formamide; acetonitrile;