N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclohexyl-6-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-2-pyridinecarbohydrazide trifIouroacetate

Base Information

Chemical Name:N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclohexyl-6-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-2-pyridinecarbohydrazide trifIouroacetate
CAS No.:1055926-01-6
Molecular Formula:C₂HF₃O₂*C₃₄H₄₃N₁₁O
Molecular Weight:735.812
Hs Code.:

N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclohexyl-6-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-2-pyridinecarbohydrazide trifIouroacetate

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Chemical Property of N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclohexyl-6-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-2-pyridinecarbohydrazide trifIouroacetate

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Technology Process of N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclohexyl-6-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-2-pyridinecarbohydrazide trifIouroacetate

There total 11 articles about N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclohexyl-6-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-2-pyridinecarbohydrazide trifIouroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1055926-00-5
N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclohexyl-6-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-2-pyridinecarbohydrazide

: 76-05-1
trifluoroacetic acid

: 1055926-01-6
N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclohexyl-6-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-2-pyridinecarbohydrazide trifIouroacetate

Guidance literature:: In acetonitrile;

Reference yield:

: 21190-87-4
6-bromo-pyridine-2-carboxylic acid

: 1055926-01-6
N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclohexyl-6-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-2-pyridinecarbohydrazide trifIouroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.25 h / 20 °C

1.2: 20 h / 95 °C / Heating / reflux

1.3: pH 3

2.1: thionyl chloride / 2 h / Heating / reflux

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

4.1: tetrahydrofuran / 19 h / 60 °C / Heating / reflux

5.1: acetonitrile

With thionyl chloride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; acetonitrile;

Reference yield:

: 1055927-13-3
1,1-dimethylethyl 2-[2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl]-2-cyclohexylhydrazinecarboxylate

: 1055926-01-6
N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclohexyl-6-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-2-pyridinecarbohydrazide trifIouroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1,1'-bis-(diphenylphosphino)ferrocene; zinc / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 3 h / 150 °C

2.1: Dowex 50x2-200 resin / ethanol / 26 h / 20 °C / Heating / reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h

3.2: 20 - 60 °C

4.1: toluene-4-sulfonic acid / acetonitrile / 20 °C

4.2: 0 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

6.1: tetrahydrofuran / 19 h / 60 °C / Heating / reflux

7.1: acetonitrile

With 1,1'-bis-(diphenylphosphino)ferrocene; Dowex 50x2-200 resin; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; ethanol; ISOPROPYLAMIDE; N,N-dimethyl-formamide; acetonitrile;