N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclohexyl-6-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-2-pyridinecarbohydrazide

Base Information

Chemical Name:N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclohexyl-6-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-2-pyridinecarbohydrazide
CAS No.:1055926-00-5
Molecular Formula:C₃₄H₄₃N₁₁O
Molecular Weight:621.789
Hs Code.:

Synonyms:N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclohexyl-6-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-2-pyridinecarbohydrazide

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Chemical Property of N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclohexyl-6-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-2-pyridinecarbohydrazide

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Technology Process of N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclohexyl-6-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-2-pyridinecarbohydrazide

There total 10 articles about N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclohexyl-6-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-2-pyridinecarbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1055927-70-2
6-[4-(chloromethyl)phenyl]-N'-{2-cyano-9-[2-(dimethylamino) ethyl]-9H-purin-6-yl}-N'-cyclohexyl-2-pyridinecarbohydrazide

: 1055926-00-5
N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclohexyl-6-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-2-pyridinecarbohydrazide

Guidance literature:: In tetrahydrofuran; at 60 ℃; for 19h; Heating / reflux;

Reference yield:

: 21190-87-4
6-bromo-pyridine-2-carboxylic acid

: 1055926-00-5
N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclohexyl-6-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-2-pyridinecarbohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.25 h / 20 °C

1.2: 20 h / 95 °C / Heating / reflux

1.3: pH 3

2.1: thionyl chloride / 2 h / Heating / reflux

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

4.1: tetrahydrofuran / 19 h / 60 °C / Heating / reflux

With thionyl chloride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane;

Reference yield:

: 1055927-13-3
1,1-dimethylethyl 2-[2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl]-2-cyclohexylhydrazinecarboxylate

: 1055926-00-5
N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclohexyl-6-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-2-pyridinecarbohydrazide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,1'-bis-(diphenylphosphino)ferrocene; zinc / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 3 h / 150 °C

2.1: Dowex 50x2-200 resin / ethanol / 26 h / 20 °C / Heating / reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h

3.2: 20 - 60 °C

4.1: toluene-4-sulfonic acid / acetonitrile / 20 °C

4.2: 0 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

6.1: tetrahydrofuran / 19 h / 60 °C / Heating / reflux

With 1,1'-bis-(diphenylphosphino)ferrocene; Dowex 50x2-200 resin; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; ethanol; ISOPROPYLAMIDE; N,N-dimethyl-formamide; acetonitrile;