2-{4-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-2-oxo-1,2-dihydropyridin-1-yl}-3-phenylpropanoic acid

Base Information

Chemical Name:2-{4-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-2-oxo-1,2-dihydropyridin-1-yl}-3-phenylpropanoic acid
CAS No.:1445961-68-1
Molecular Formula:C₂₁H₁₆ClN₅O₃
Molecular Weight:421.843
Hs Code.:

Synonyms:2-{4-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-2-oxo-1,2-dihydropyridin-1-yl}-3-phenylpropanoic acid

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Chemical Property of 2-{4-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-2-oxo-1,2-dihydropyridin-1-yl}-3-phenylpropanoic acid

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Technology Process of 2-{4-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-2-oxo-1,2-dihydropyridin-1-yl}-3-phenylpropanoic acid

There total 8 articles about 2-{4-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-2-oxo-1,2-dihydropyridin-1-yl}-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.6%

: methyl 2-(4-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)-2-oxopyridin-1 (2H)-yl)-3-phenylpropanoate

: 1445961-68-1
2-{4-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-2-oxo-1,2-dihydropyridin-1-yl}-3-phenylpropanoic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 - 30 ℃; for 5h;

Reference yield:

: 1073371-77-3
4-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine

: 1445961-68-1
2-{4-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-2-oxo-1,2-dihydropyridin-1-yl}-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydrogencarbonate / 1,4-dioxane; water / 110 °C / Inert atmosphere

2.1: acetic acid / 0.08 h / 20 - 30 °C

2.2: 80 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 5 h / 20 - 30 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; sodium hydrogencarbonate; acetic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 873-38-1
4-chloro-2-bromoaniline

: 1445961-68-1
2-{4-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-2-oxo-1,2-dihydropyridin-1-yl}-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 24 h / 80 °C / Inert atmosphere

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydrogencarbonate / 1,4-dioxane; water / 110 °C / Inert atmosphere

3.1: acetic acid / 0.08 h / 20 - 30 °C

3.2: 80 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 5 h / 20 - 30 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; potassium acetate; sodium hydrogencarbonate; acetic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide;