4-[(3,5-dichloro-2-iodo-benzoyl)-(4-methoxy-benzyl)-amino]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-[(3,5-dichloro-2-iodo-benzoyl)-(4-methoxy-benzyl)-amino]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester
CAS No.:1185755-24-1
Molecular Formula:C₂₅H₂₇Cl₂IN₂O₄
Molecular Weight:617.311
Hs Code.:

Synonyms:4-[(3,5-dichloro-2-iodo-benzoyl)-(4-methoxy-benzyl)-amino]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-[(3,5-dichloro-2-iodo-benzoyl)-(4-methoxy-benzyl)-amino]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Chemical Property:

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Technology Process of 4-[(3,5-dichloro-2-iodo-benzoyl)-(4-methoxy-benzyl)-amino]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

There total 7 articles about 4-[(3,5-dichloro-2-iodo-benzoyl)-(4-methoxy-benzyl)-amino]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1017540-71-4
C₁₈H₂₆N₂O₃

: 42860-31-1
3,5-dichloro-2-iodobenzoyl chloride

: 1185755-24-1
4-[(3,5-dichloro-2-iodo-benzoyl)-(4-methoxy-benzyl)-amino]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Guidance literature:: With triethylamine; In toluene; Reflux;

Reference yield:

: 51-36-5
3,5-dichlorobenzoic acid

: 1185755-24-1
4-[(3,5-dichloro-2-iodo-benzoyl)-(4-methoxy-benzyl)-amino]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid; nitric acid / 0 - 20 °C

2.1: hydrogen / rhenium; nickel / methanol / 20 °C

3.1: hydrogenchloride; sodium hydroxide; sodium nitrite / water / 0 - 5 °C

3.2: 0.5 h / 50 °C

4.1: thionyl chloride / Reflux

5.1: triethylamine / toluene / Reflux

With hydrogenchloride; thionyl chloride; sulfuric acid; hydrogen; nitric acid; triethylamine; sodium hydroxide; sodium nitrite; rhenium; nickel; In methanol; water; toluene;

Reference yield:

: 23082-45-3
3,5-dichloro-2-nitrobenzoic acid

: 1185755-24-1
4-[(3,5-dichloro-2-iodo-benzoyl)-(4-methoxy-benzyl)-amino]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / rhenium; nickel / methanol / 20 °C

2.1: hydrogenchloride; sodium hydroxide; sodium nitrite / water / 0 - 5 °C

2.2: 0.5 h / 50 °C

3.1: thionyl chloride / Reflux

4.1: triethylamine / toluene / Reflux

With hydrogenchloride; thionyl chloride; hydrogen; triethylamine; sodium hydroxide; sodium nitrite; rhenium; nickel; In methanol; water; toluene;