23082-45-3

Basic information

• Product Name: 3,5-Dichloro-2-nitrobenzoic acid
• Synonyms: 3,5-Dichloro-2-nitrobenzoic acid
• CAS NO: 23082-45-3
• Molecular Formula: C₇H₃Cl₂NO₄
• Molecular Weight: 0
• Mol File: 23082-45-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,5-Dichloro-2-nitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dichloro-2-nitrobenzoic acid(23082-45-3)
• EPA Substance Registry System: 3,5-Dichloro-2-nitrobenzoic acid(23082-45-3)

Safety Data

• Hazardous Substances Data: 23082-45-3(Hazardous Substances Data)

Upstream product

• 2789-92-6 3,5-dichloroantranilic acid 
• 51-36-5 3,5-dichlorobenzoic acid 
• 7697-37-2 nitric acid 
• 118665-00-2 2,4-dichloro-6-methylnitrobenzene 
• 10203-08-4 3,5-dichlorobenzaldehyde 
• 59178-12-0 3,5-dichloro-2-nitrobenzaldehyde 

Downstream Products

• 229342-55-6 N-(5-chloro-2-pyridinyl)-2-nitro-3,5-dichlorophenylcarboxamide 
• 42860-31-1 3,5-dichloro-2-iodobenzoyl chloride 
• 1185755-24-1 4-[(3,5-dichloro-2-iodo-benzoyl)-(4-methoxy-benzyl)-amino]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 1267952-21-5 2,4-dichloro-6-hydroxymethylnitrobenzene 
• 1267952-23-7 2,4-dichloro-6-methoxymethylnitrobenzene 
• 569328-81-0 (5-chloro-3-methoxymethyl-2-nitrophenyl)(4,6-dimethoxypyrimidin-2-yl)ketone 
• 569328-84-3 (5-chloro-3-methoxymethyl-2-nitrophenyl)(4,6-dimethoxypyrimidin-2-yl)acetonitrile 
• 2789-92-6 3,5-dichloroantranilic acid 

Relevant articles and documents

Synthesis of novel quinazolinone derivatives with methyl (E)-2-(3-methoxy)acrylate moiety

A new series of quinazolinone derivatives with methyl (E)-2-(3-methoxy) acrylate moiety have been designed and synthesized. All target compounds had been identified by 1H NMR spectrum, IR spectrum and HR-MS (high resolution mass spectrum). Three target compounds (10a, 10e, 10h) were chosen to preliminarily test the antibacterial activities, the results showed that all three target compounds exhibited antibacterial activities against three bacterial strains (Proteobacteria, Salmonella, Colibacillus).

Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

Systematic SAR studies of in vitro factor Xa inhibitory activity around compound 1 were performed by modifying each of the three phenyl rings. A class of highly potent, selective, efficacious and orally bioavailable direct factor Xa inhibitors was discovered. These compounds were screened in hERG binding assays to examine the effects of substitution groups on the hERG channel affinity. From the leading compounds, betrixaban (compound 11, PRT054021) has been selected as the clinical candidate for development.

Quaternary amidino based inhibitors of factor xa

Novel quaternary amidino-containing compounds of the general formulae (I), (II), (III), (IV), (V) and (VI): including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa