[(S)-1-(2-Bromo-3,5-dimethoxy-phenyl)-2-(2-methoxy-ethoxymethoxy)-ethyl]-carbamic acid benzyl ester

Base Information

• Chemical Name: [(S)-1-(2-Bromo-3,5-dimethoxy-phenyl)-2-(2-methoxy-ethoxymethoxy)-ethyl]-carbamic acid benzyl ester
• CAS No.: 253276-88-9
• Molecular Formula: C₂₂H₂₈BrNO₇
• Molecular Weight: 498.371

Synonyms:[(S)-1-(2-Bromo-3,5-dimethoxy-phenyl)-2-(2-methoxy-ethoxymethoxy)-ethyl]-carbamic acid benzyl ester

Chemical Property of [(S)-1-(2-Bromo-3,5-dimethoxy-phenyl)-2-(2-methoxy-ethoxymethoxy)-ethyl]-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(S)-1-(2-Bromo-3,5-dimethoxy-phenyl)-2-(2-methoxy-ethoxymethoxy)-ethyl]-carbamic acid benzyl ester

There total 3 articles about [(S)-1-(2-Bromo-3,5-dimethoxy-phenyl)-2-(2-methoxy-ethoxymethoxy)-ethyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Methoxyethoxymethyl chloride (3970-21-6) + [(S)-1-(2-Bromo-3,5-dimethoxy-phenyl)-2-hydroxy-ethyl]-carbamic acid benzyl ester (253276-87-8) → [(S)-1-(2-Bromo-3,5-dimethoxy-phenyl)-2-(2-methoxy-ethoxymethoxy)-ethyl]-carbamic acid benzyl ester (253276-88-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; at 25 ℃; for 22h;

DOI:10.1021/ja992577q

Reference yield:

3,5-dimethoxystyrene (40243-87-6) → [(S)-1-(2-Bromo-3,5-dimethoxy-phenyl)-2-(2-methoxy-ethoxymethoxy)-ethyl]-carbamic acid benzyl ester (253276-88-9)

Guidance literature:

Multi-step reaction with 3 steps

1: (DHQ)2PHAL; K₂Os₂(OH)4; t-BuOCl / aq. NaOH; propan-1-ol / 0.5 h / 25 °C

2: NBS / acetonitrile / 0.5 h / 0 °C

3: i-Pr₂NEt / CH₂Cl₂; tetrahydrofuran / 22 h / 25 °C

With potassium osmate; N-Bromosuccinimide; Hydroquinone 1,4-phthalazinediyl diether; tert-butylhypochlorite; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; propan-1-ol; sodium hydroxide; dichloromethane; acetonitrile; 1: asymmetric aminohydroxylation / 2: Bromination / 3: Alkylation;

DOI:10.1021/ja992577q

Reference yield:

(S)-benzyl (1-(3,5-dimethoxyphenyl)-2-hydroxyethyl)carbamate (199392-80-8) → [(S)-1-(2-Bromo-3,5-dimethoxy-phenyl)-2-(2-methoxy-ethoxymethoxy)-ethyl]-carbamic acid benzyl ester (253276-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NBS / acetonitrile / 0.5 h / 0 °C

2: i-Pr₂NEt / CH₂Cl₂; tetrahydrofuran / 22 h / 25 °C

With N-Bromosuccinimide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile; 1: Bromination / 2: Alkylation;

DOI:10.1021/ja992577q

upstream raw materials:

2-Methoxyethoxymethyl chloride

[(S)-1-(2-Bromo-3,5-dimethoxy-phenyl)-2-hydroxy-ethyl]-carbamic acid benzyl ester

3,5-dimethoxystyrene

(S)-benzyl (1-(3,5-dimethoxyphenyl)-2-hydroxyethyl)carbamate

Downstream raw materials:

C₆₆H₇₇ClFN₉O₂₁

C₆₁H₇₇ClN₄O₁₈Si

C₅₄H₆₁ClN₄O₁₈

C₅₅H₆₃ClN₄O₁₈

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 253276-88-9 [(S)-1-(2-Bromo-3,5-dimethoxy-phenyl)-2-(2-methoxy-ethoxymethoxy)-ethyl]-carbamic acid benzyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send