40243-87-6

Upstream product

• 88106-84-7 β-(3,5-Dimethoxyphenyl)ethanesulfonyl azide 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 19493-09-5 Methylenetriphenylphosphorane 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 14950-55-1 rac-1-(3,5-dimethoxyphenyl)ethan-1-ol 
• 637-69-4 4-Methoxystyrene 
• 2628-16-2 p-acetoxystyrene 
• 75-36-5 acetyl chloride 
• 7440-66-6 zinc 
• 2768-02-7 (vinyl)trimethoxylsilane 
• 25245-27-6 1-iodo-3,5-dimethoxybenzene 
• 7051-16-3 1-chloro-3,5-dimethoxybenzene 
• 110-91-8 morpholine 

Downstream Products

• 178216-96-1 (R)-1-(3,5-Dimethoxy-phenyl)-ethane-1,2-diol 
• 199392-80-8 (S)-benzyl (1-(3,5-dimethoxyphenyl)-2-hydroxyethyl)carbamate 
• 39151-19-4 1-(3,5-dimethoxyphenyl)ethan-1-one 
• 585521-15-9 4-[(E)-2-(3,5-Dimethoxy-phenyl)-vinyl]-benzoic acid ethyl ester 
• 22255-22-7 3,5,4'-trimethoxy-trans-stilbene 
• 4705-34-4 1,2-bis(4-methoxyphenyl)ethene 
• 80715-09-9 (E)-3,3',5,5'-tetramethoxystilbene 
• 659-22-3 trans-4,4'-dihydroxystilbene 
• 65819-34-3 (E)-4-hydroxy-4'-methoxystilbene 
• 78398-38-6 1,3-Dimethoxy-5-[1-(2,2,2-trifluoro-ethoxy)-ethyl]-benzene 
• 6325-63-9 (E)-3,3'-dimethoxystilbene 
• 18869-29-9 (E)-4,4'-dimethylstilbene 
• 880354-46-1 1-[(E)-2-(4-methylphenyl)ethenyl]-3,5-dimethoxybenzene 

Relevant academic research and scientific papers

Antibody-catalyzed enantioselective Norrish type II cyclization

Excellent enantioselectivity (up to 96% ee) was attained in an antibodycatalyzed photochemical Norrish type II reaction, which proceeded via the intermediate diradical 1 to produce the cyclobutanols 4 (absolute stereochemistry unknown). Use of the antibod

Highly selective flurogenic chemosensor for cyanide ion in aqueous medium and its applications of logic gate and Hela cells

We have successfully synthesized triphenylamine-based fluorophores (MK and HK) with cyanoacrylic acid as a receptor for CN– ion sensing in a 99% aqueous medium. From the emission titration spectra, the detection limit of cyanide ion calculated towards MK and HK, respectively, are 234 nM and 11 nM. The observed binding constants for MK and HK, respectively, are 27 × 10-3 M and 10 X 10-2 M. The plausible sensing mechanism is confirmed by various methods such as Job's plot experiment, proton NMR titration, and density functional theory. Furthermore, the prominent application is the naked-eye detection of cyanide from non-fluorescent to greenish-yellow fluorescent under 365 nm UV light. Based on the observed data from fluorescence spectroscopic studies, a new logic circuit is designed. Moreover, the potential application of HK and MK in the Hela cell line exhibited turn on fluorescence image for cyanide ion through the inhibition of the ICT process. In addition to that, the probe MK and HK is successfully applied in the analysis of the real sample for the rapid detection of cyanide ions.

Functionalized styrene synthesis via palladium-catalyzed C[sbnd]C cleavage of aryl ketones

We report herein the synthesis of functionalized styrenes via palladium-catalyzed Suzuki–Miyaura cross-coupling reaction between aryl ketone derivatives and potassium vinyltrifluoroborate. The employment of pyridine-oxazoline ligand was the key to the cleavage of unstrained C[sbnd]C bond. A variety of functional groups and biologically important moleculars were well tolerated. The orthogonal Suzuki–Miyaura coupling demonstrated the synthetic practicability.

Nickel-Catalyzed Reductive Cross-Coupling of Aryl Bromides with Vinyl Acetate in Dimethyl Isosorbide as a Sustainable Solvent

A nickel-catalyzed reductive cross-coupling has been achieved using (hetero)aryl bromides and vinyl acetate as the coupling partners. This mild, applicable method provides a reliable access to a variety of vinyl arenes, heteroarenes, and benzoheterocycles, which should expand the chemical space of precursors to fine chemicals and polymers. Importantly, a sustainable solvent, dimethyl isosorbide, is used, making this protocol more attractive from the point of view of green chemistry.

Synthesis, Biological Evaluation of ortho-Carboxamidostilbenes as Potential Inhibitors of Hyperglycemic Enzymes, and Molecular Docking Study

A new series of ortho-carboxamidostilbenes derivatives were synthesized via Heck Coupling and screened for their α-amylase and α-glucosidase inhibitory potential. The results indicated that all the synthesized compounds showed a substantial α-glucosidase

Design of Negative and Positive Allosteric Modulators of the Cannabinoid CB2Receptor Derived from the Natural Product Cannabidiol

Cannabidiol (CBD), the second most abundant of the active compounds found in the Cannabis sativa plant, is of increasing interest because it is approved for human use and is neither euphorizing nor addictive. Here, we design and synthesize novel compounds taking into account that CBD is both a partial agonist, when it binds to the orthosteric site, and a negative allosteric modulator, when it binds to the allosteric site of the cannabinoid CB2 receptor. Molecular dynamic simulations and site-directed mutagenesis studies have identified the allosteric site near the receptor entrance. This knowledge has permitted to perform structure-guided design of negative and positive allosteric modulators of the CB2 receptor with potential therapeutic utility.

Hydrazide-Catalyzed Polyene Cyclization: Asymmetric Organocatalytic Synthesis of cis-Decalins

Polyene cyclizations offer rapid entry into terpenoid ring systems. Although enantioselective cyclizations of (E)-polyenes to form trans-decalin ring systems are well precedented, highly enantioselective cyclizations of (Z)-polyenes to form the correspond

Preparation method of alkyl nitrile compound

The invention discloses a preparation method of an alkyl nitrile compound. Specifically, the preparation method comprises the following step: in an organic solvent, in the presence of a protective gasand under the action of a catalyst, carrying out a reduction reaction as shown in the specification on olefin as shown in a formula I, a cyanation reagent and water, wherein the alkyl nitrile compound 1 is a compound II and/or a compound III. The preparation method provided by the invention is mild in condition, can realize hydrocyanation of olefin more safely and efficiently, and has good substrate universality and functional group compatibility.

cis-Selective Transfer Semihydrogenation of Alkynes by Merging Visible-Light Catalysis with Cobalt Catalysis

Herein, the first example of visible-light-driven, cobalt-catalyzed transfer semihydrogenation of alkynes to alkenes is reported. It is carried out by using Ir[dF(CF3)ppy]2(dtbbpy)]PF6 as photosensitizer, CoBr2/n-Bu3P as proton-reducing catalyst, and i-Pr2NEt/AcOH as the hydrogen source. Under the established catalytic system, the semihydrogenation proceeds with Z as the major selectivity and with inhibition of over-reduction. Under mild reaction conditions, both internal and terminal alkynes, as well as reducible functional groups such as halogen, cyano, and ester, are tolerated. Preliminary mechanistic studies revealed the dual role of the photosensitizer in initiating the reaction via a single-electron transfer process and controlling the stereoselectivity via an energy transfer process. (Figure presented.).

Selective Transfer Semihydrogenation of Alkynes with H2O (D2O) as the H (D) Source over a Pd-P Cathode

We reported a selective semihydrogenation (deuteration) of numerous terminal and internal alkynes using H2O (D2O) as the H (D) source over a Pd-P alloy cathode at a lower potential. P-doping caused the enhanced specific adsorption of alkynes and the promoted intrinsic activity for producing adsorbed atomic hydrogen (H*ads) from water electrolysis. The semihydrogenation of alkynes could be accomplished at a lower potential with up to 99 % selectivity and 78 % Faraday efficiency of alkene products, outperforming pure Pd and commercial Pd/C. This electrochemical semihydrogenation of alkynes might proceed via a H*ads addition pathway rather than a proton-coupled electron transfer process. The decreased amount of H*ads at a lower potential and the more preferential adsorption of the Pd-P to C≡C π bond than C=C moiety resulted in the excellent alkene selectivity. This method was capable of producing mono-, di-, and tri-deuterated alkenes with up to 99 % deuterium incorporation.