t-butyl [[1-[1-(p-cyanobenzoyl)-2-methyl-L-prolyl]-4-piperidinyl]oxy]acetate

Base Information

Chemical Name:t-butyl [[1-[1-(p-cyanobenzoyl)-2-methyl-L-prolyl]-4-piperidinyl]oxy]acetate
CAS No.:144412-15-7
Molecular Formula:C₂₅H₃₃N₃O₅
Molecular Weight:455.554
Hs Code.:

Synonyms:t-butyl [[1-[1-(p-cyanobenzoyl)-2-methyl-L-prolyl]-4-piperidinyl]oxy]acetate

Suppliers and Price of t-butyl [[1-[1-(p-cyanobenzoyl)-2-methyl-L-prolyl]-4-piperidinyl]oxy]acetate

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Chemical Property of t-butyl [[1-[1-(p-cyanobenzoyl)-2-methyl-L-prolyl]-4-piperidinyl]oxy]acetate

Chemical Property:

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Technology Process of t-butyl [[1-[1-(p-cyanobenzoyl)-2-methyl-L-prolyl]-4-piperidinyl]oxy]acetate

There total 8 articles about t-butyl [[1-[1-(p-cyanobenzoyl)-2-methyl-L-prolyl]-4-piperidinyl]oxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 144412-15-7
t-butyl [[1-[1-(p-cyanobenzoyl)-2-methyl-L-prolyl]-4-piperidinyl]oxy]acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / triethylamine (TEA) / CH₂Cl₂ / 16 h / Ambient temperature

2: 76 percent / tetra-n-butylammonium hydrogen sulfate, aq. NaOH / CH₂Cl₂; H₂O / 16 h

3: 94 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 760 Torr

4: tetrahydrofuran

With sodium hydroxide; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jm00101a017

Reference yield:

: 95798-23-5
1-(benzyloxycarbonyl)-4-hydroxypiperidine

: 144412-15-7
t-butyl [[1-[1-(p-cyanobenzoyl)-2-methyl-L-prolyl]-4-piperidinyl]oxy]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / tetra-n-butylammonium hydrogen sulfate, aq. NaOH / CH₂Cl₂; H₂O / 16 h

2: 94 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 760 Torr

3: tetrahydrofuran

With sodium hydroxide; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jm00101a017

Reference yield:

: 144412-43-1
t-Butyl 2-(1-benzyloxycarbonyl-4-piperidyl)oxyacetate

: 144412-15-7
t-butyl [[1-[1-(p-cyanobenzoyl)-2-methyl-L-prolyl]-4-piperidinyl]oxy]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 760 Torr

2: tetrahydrofuran

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00101a017