1-Piperidinecarboxylic acid, 4-[2-(1,1-dimethylethoxy)-2-oxoethoxy]-, phenylmethyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 4-[2-(1,1-dimethylethoxy)-2-oxoethoxy]-, phenylmethyl ester
• CAS No.: 144412-43-1
• Molecular Formula: C19H27NO5
• Molecular Weight: 349.427
• Mol file: 144412-43-1.mol

Synonyms:t-butyl 1-(benzyloxycarbonyl)piperidin-4-yloxyacetate;BENZYL 4-(2-TERT-BUTOXY-2-OXOETHOXY)PIPERIDINE-1-CARBOXYLATE;t-butyl 2-[(1-benzyloxycarbonyl-4-piperidinyl)oxy]acetate;N-benzyloxycarbonyl-4-[(t-butoxy carbonyl) methoxy]-piperidine;t-butyl [N-benzyloxycarbonyl-4-piperidinyloxy]acetate;benzyl 4-<(tert-butyloxycarbonyl)methoxy>-1-piperidinecarboxylate;

Chemical Property of 1-Piperidinecarboxylic acid, 4-[2-(1,1-dimethylethoxy)-2-oxoethoxy]-, phenylmethyl ester

Chemical Property:

• PSA: 65.07000
• LogP: 3.08380

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-[2-(1,1-dimethylethoxy)-2-oxoethoxy]-, phenylmethyl ester

There total 7 articles about 1-Piperidinecarboxylic acid, 4-[2-(1,1-dimethylethoxy)-2-oxoethoxy]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(benzyloxycarbonyl)-4-hydroxypiperidine (95798-23-5) + bromoacetic acid tert-butyl ester (5292-43-3) → t-Butyl 2-(1-benzyloxycarbonyl-4-piperidyl)oxyacetate (144412-43-1)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In water; toluene; for 20h;

DOI:10.1016/S0045-2068(02)00013-5

Reference yield: 84.0%

sodium hydrogencarbonate (144-55-8) + benzyl chloroformate (501-53-1,94274-21-2) + (Piperidin-4-yloxy)-acetic acid tert-butyl ester (144412-03-3) → t-Butyl 2-(1-benzyloxycarbonyl-4-piperidyl)oxyacetate (144412-43-1)

Guidance literature:

With triethylamine; In dichloromethane;

Reference yield:

1-(benzyloxycarbonyl)-4-hydroxypiperidine (95798-23-5) + bromoacetic acid tert-butyl ester (5292-43-3) + tetra(n-butyl)ammonium hydrogen sulfate → t-Butyl 2-(1-benzyloxycarbonyl-4-piperidyl)oxyacetate (144412-43-1)

Guidance literature:

With sodium hydroxide; In water; toluene;

upstream raw materials:

1-(benzyloxycarbonyl)-4-hydroxypiperidine

bromoacetic acid tert-butyl ester

4-HYDROXYPIPERIDINE

benzyl chloroformate

Downstream raw materials:

2-(1-[(benzyloxy)carbonyl]-4-piperidyloxy)acetic acid

{1-[(S)-2-(4-Carbamimidoyl-benzoylamino)-propionyl]-piperidin-4-yloxy}-acetic acid tert-butyl ester

[1-((R)-2-Benzyloxycarbonylamino-propionyl)-piperidin-4-yloxy]-acetic acid tert-butyl ester

[1-((S)-2-Benzyloxycarbonylamino-propionyl)-piperidin-4-yloxy]-acetic acid tert-butyl ester

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