Technology Process of 7,9-anisaldehyde acetal-9-desoxo-10-epi-baccatin III
There total 11 articles about 7,9-anisaldehyde acetal-9-desoxo-10-epi-baccatin III which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium borohydride;
In
tetrahydrofuran;
at -13 - 0 ℃;
for 7.25h;
Cooling with ice/water/ammonium chloride;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: water; hydrazine / Isopropyl acetate / 1 h / 20 °C
2: dmap / dichloromethane / 3 h / 20 °C
3: tetra-n-propylammonium perruthenate.; 4-methylmorpholine N-oxide / dichloromethane / 22 h / 20 °C
4: sodium tetrahydroborate / methanol; ethanol / 5 h / 0 °C
5: dmap / dichloromethane / 15 h / 20 °C
6: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C
7: toluene-4-sulfonic acid / dichloromethane / 0.75 h / 20 °C
8: lithium borohydride / tetrahydrofuran / 7.25 h / -13 - 0 °C / Cooling with ice/water/ammonium chloride
With
dmap; sodium tetrahydroborate; lithium borohydride; tetra-n-propylammonium perruthenate.; tetrabutyl ammonium fluoride; water; 4-methylmorpholine N-oxide; hydrazine;
toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; Isopropyl acetate;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium tetrahydroborate / methanol; ethanol / 5 h / 0 °C
2: triethylamine / dichloromethane / 20 °C
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C
4: toluene-4-sulfonic acid / dichloromethane / 0.75 h / 20 °C
5: lithium borohydride / tetrahydrofuran / 7.25 h / -13 - 0 °C / Cooling with ice/water/ammonium chloride
With
sodium tetrahydroborate; lithium borohydride; tetrabutyl ammonium fluoride; triethylamine;
toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; ethanol; dichloromethane;
