9-desoxo-7,9-anisaldehyde acetal 10-epipaclitaxel

Base Information

Chemical Name:9-desoxo-7,9-anisaldehyde acetal 10-epipaclitaxel
CAS No.:849213-09-8
Molecular Formula:C₅₅H₅₉NO₁₅
Molecular Weight:974.071
Hs Code.:

Synonyms:9-desoxo-7,9-anisaldehyde acetal 10-epipaclitaxel

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Chemical Property of 9-desoxo-7,9-anisaldehyde acetal 10-epipaclitaxel

Chemical Property:

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Technology Process of 9-desoxo-7,9-anisaldehyde acetal 10-epipaclitaxel

There total 9 articles about 9-desoxo-7,9-anisaldehyde acetal 10-epipaclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 162809-96-3
9-α-OH-9-desoxo-10-epipaclitaxel

: 849213-09-8
9-desoxo-7,9-anisaldehyde acetal 10-epipaclitaxel

Guidance literature:: toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 0.75h;

Reference yield:

: 33069-62-4
taxol

: 849213-09-8
9-desoxo-7,9-anisaldehyde acetal 10-epipaclitaxel

Guidance literature:: Multi-step reaction with 8 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 h / 20 °C

2: water; hydrazine / Isopropyl acetate / 1 h / 20 °C

3: dmap / dichloromethane / 3 h / 20 °C

4: tetra-n-propylammonium perruthenate.; 4-methylmorpholine N-oxide / dichloromethane / 22 h / 20 °C

5: sodium tetrahydroborate / methanol; ethanol / 5 h / 0 °C

6: dmap / dichloromethane / 15 h / 20 °C

7: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

8: toluene-4-sulfonic acid / dichloromethane / 0.75 h / 20 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; tetra-n-propylammonium perruthenate.; tetrabutyl ammonium fluoride; water; 4-methylmorpholine N-oxide; hydrazine; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; Isopropyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 114655-02-6
2'-O-(tert-butyldimethylsilyl)paclitaxel

: 849213-09-8
9-desoxo-7,9-anisaldehyde acetal 10-epipaclitaxel

Guidance literature:: Multi-step reaction with 7 steps

1: water; hydrazine / Isopropyl acetate / 1 h / 20 °C

2: dmap / dichloromethane / 3 h / 20 °C

3: tetra-n-propylammonium perruthenate.; 4-methylmorpholine N-oxide / dichloromethane / 22 h / 20 °C

4: sodium tetrahydroborate / methanol; ethanol / 5 h / 0 °C

5: dmap / dichloromethane / 15 h / 20 °C

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

7: toluene-4-sulfonic acid / dichloromethane / 0.75 h / 20 °C

With dmap; sodium tetrahydroborate; tetra-n-propylammonium perruthenate.; tetrabutyl ammonium fluoride; water; 4-methylmorpholine N-oxide; hydrazine; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; Isopropyl acetate;