methyl [1-({4-[(3,4-dichlorabenzyl)oxy]phenyl}carbonyl)isoquinolin-4-yl]acetate

Base Information

Chemical Name:methyl [1-({4-[(3,4-dichlorabenzyl)oxy]phenyl}carbonyl)isoquinolin-4-yl]acetate
CAS No.:1233249-56-3
Molecular Formula:C₂₆H₁₉Cl₂NO₄
Molecular Weight:480.347
Hs Code.:

Synonyms:methyl [1-({4-[(3,4-dichlorabenzyl)oxy]phenyl}carbonyl)isoquinolin-4-yl]acetate

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Chemical Property of methyl [1-({4-[(3,4-dichlorabenzyl)oxy]phenyl}carbonyl)isoquinolin-4-yl]acetate

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Technology Process of methyl [1-({4-[(3,4-dichlorabenzyl)oxy]phenyl}carbonyl)isoquinolin-4-yl]acetate

There total 15 articles about methyl [1-({4-[(3,4-dichlorabenzyl)oxy]phenyl}carbonyl)isoquinolin-4-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1233249-55-2
methyl {1-[(4-hydroxyphenyl)carbonyl]isoquinolin-4-yl} acetate

: 18880-04-1
3,4-dichlorobenzyl bromide

: 1233249-56-3
methyl [1-({4-[(3,4-dichlorabenzyl)oxy]phenyl}carbonyl)isoquinolin-4-yl]acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1016/j.bmcl.2012.03.009

Reference yield:

: 1233249-54-1
methyl {1-[(4-methoxyphenyl)carbonyl]isoquinolin-4-yl} acetate

: 1233249-56-3
methyl [1-({4-[(3,4-dichlorabenzyl)oxy]phenyl}carbonyl)isoquinolin-4-yl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: boron tribromide / chloroform / 2 h / 20 °C / Cooling with ice

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

With boron tribromide; potassium carbonate; In chloroform; N,N-dimethyl-formamide;

Reference yield:

: 37497-86-2
1-chloro-isoquinoline-4-carboxylic acid methyl ester

: 1233249-56-3
methyl [1-({4-[(3,4-dichlorabenzyl)oxy]phenyl}carbonyl)isoquinolin-4-yl]acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hexamethyldisilazane / 0 °C

2.1: oxygen / 20 °C

3.1: methanol; water; sodium hydroxide / 0 - 20 °C

4.1: oxalyl dichloride / chloroform / 20 °C

5.1: silver(I) acetate / tetrahydrofuran; acetonitrile / 20 °C

5.2: 60 °C

6.1: diazomethyl-trimethyl-silane / 20 °C

7.1: boron tribromide / chloroform / 0 - 20 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

With methanol; oxalyl dichloride; water; oxygen; silver(I) acetate; sodium hexamethyldisilazane; boron tribromide; potassium carbonate; sodium hydroxide; diazomethyl-trimethyl-silane; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; acetonitrile; 5.2: Wolff rearrangement;
DOI:10.1016/j.bmcl.2012.03.009