2-[1-[4-[(3,4-dichlorophenyl)methoxy]benzoyl]isoquinolin-4-yl]acetic acid

Base Information

Chemical Name:2-[1-[4-[(3,4-dichlorophenyl)methoxy]benzoyl]isoquinolin-4-yl]acetic acid
CAS No.:1233248-10-6
Molecular Formula:C₂₅H₁₇Cl₂NO₄
Molecular Weight:466.32
Hs Code.:

Synonyms:2-[1-[4-[(3,4-dichlorophenyl)methoxy]benzoyl]isoquinolin-4-yl]acetic acid

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Chemical Property of 2-[1-[4-[(3,4-dichlorophenyl)methoxy]benzoyl]isoquinolin-4-yl]acetic acid

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Technology Process of 2-[1-[4-[(3,4-dichlorophenyl)methoxy]benzoyl]isoquinolin-4-yl]acetic acid

There total 16 articles about 2-[1-[4-[(3,4-dichlorophenyl)methoxy]benzoyl]isoquinolin-4-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1233249-56-3
methyl [1-({4-[(3,4-dichlorabenzyl)oxy]phenyl}carbonyl)isoquinolin-4-yl]acetate

: 1233248-10-6
2-[1-[4-[(3,4-dichlorophenyl)methoxy]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: With methanol; water; sodium hydroxide; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2012.03.009

Reference yield:

: 1233249-55-2
methyl {1-[(4-hydroxyphenyl)carbonyl]isoquinolin-4-yl} acetate

: 1233248-10-6
2-[1-[4-[(3,4-dichlorophenyl)methoxy]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

2: methanol; water; sodium hydroxide / tetrahydrofuran / 20 °C

With methanol; water; potassium carbonate; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.03.009

Reference yield:

: 1233249-54-1
methyl {1-[(4-methoxyphenyl)carbonyl]isoquinolin-4-yl} acetate

: 1233248-10-6
2-[1-[4-[(3,4-dichlorophenyl)methoxy]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: boron tribromide / chloroform / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 80 °C

3: methanol; water; sodium hydroxide / tetrahydrofuran / 20 °C

With methanol; water; boron tribromide; potassium carbonate; sodium hydroxide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.03.009