6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Base Information

Chemical Name:6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one
CAS No.:1613720-11-8
Molecular Formula:C₂₉H₂₈F₃N₅O₂
Molecular Weight:535.569
Hs Code.:

Synonyms:6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

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Chemical Property of 6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

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Technology Process of 6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

There total 5 articles about 6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613720-10-7
6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2-(2-trimethylsilanylethoxymethyl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

: 1613720-11-8
6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: 6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2-(2-trimethylsilanylethoxymethyl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield:

: 1613719-81-5
6-bromo-4-methyl-7-trifluoromethyl-2-(2-trimethylsilanylethoxymethyl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

: 1613720-11-8
6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 5 h / Reflux

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; In dichloromethane; toluene;

Reference yield:

: 320-49-0
3-trifluoromethyl-4-bromophenol

: 1613720-11-8
6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid; nitric acid / acetic acid / 3.5 h / 0 - 20 °C

2.1: zinc; ammonium chloride / methanol / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3.2: 3 h / 20 °C

4.1: Lawessons reagent / toluene / 1 h / Reflux

4.2: 1 h / 80 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h

5.2: 2 h / 20 °C

6.1: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 5 h / Reflux

7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With Lawessons reagent; sulfuric acid; nitric acid; palladium diacetate; sodium hydride; potassium carbonate; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; zinc; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene; mineral oil;