6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2-(2-trimethylsilanylethoxymethyl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Base Information

Chemical Name:6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2-(2-trimethylsilanylethoxymethyl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one
CAS No.:1613720-10-7
Molecular Formula:C₃₅H₄₂F₃N₅O₃Si
Molecular Weight:665.831
Hs Code.:

6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2-(2-trimethylsilanylethoxymethyl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Synonyms:6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2-(2-trimethylsilanylethoxymethyl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2-(2-trimethylsilanylethoxymethyl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2-(2-trimethylsilanylethoxymethyl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

There total 4 articles about 6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2-(2-trimethylsilanylethoxymethyl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1613719-81-5
6-bromo-4-methyl-7-trifluoromethyl-2-(2-trimethylsilanylethoxymethyl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

: 133891-52-8
3-amino-1-(diphenylmethyl)-3-methylazetidine

: 1613720-10-7
6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2-(2-trimethylsilanylethoxymethyl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; for 5h; Reflux;

Reference yield:

: 1613719-77-9
4-bromo-2-nitro-5-(trifluoromethyl)phenol

: 1613720-10-7
6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2-(2-trimethylsilanylethoxymethyl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc; ammonium chloride / methanol / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2.2: 3 h / 20 °C

3.1: Lawessons reagent / toluene / 1 h / Reflux

3.2: 1 h / 80 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h

4.2: 2 h / 20 °C

5.1: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 5 h / Reflux

With Lawessons reagent; palladium diacetate; sodium hydride; potassium carbonate; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; zinc; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1613719-78-0
2-amino-4-bromo-5-(trifluoromethyl)phenol

: 1613720-10-7
6-(1-benzhydryl-3-methylazetidin-3-ylamino)-4-methyl-7-trifluoromethyl-2-(2-trimethylsilanylethoxymethyl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

1.2: 3 h / 20 °C

2.1: Lawessons reagent / toluene / 1 h / Reflux

2.2: 1 h / 80 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h

3.2: 2 h / 20 °C

4.1: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 5 h / Reflux

With Lawessons reagent; palladium diacetate; sodium hydride; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; mineral oil;