N-(6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide

Base Information

Chemical Name:N-(6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide
CAS No.:1616235-87-0
Molecular Formula:C₂₃H₂₃FN₆O₂
Molecular Weight:434.473
Hs Code.:

Synonyms:N-(6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide

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Chemical Property of N-(6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide

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Technology Process of N-(6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide

There total 7 articles about N-(6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1162680-90-1
N-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide

: 1616235-85-8
4-bromo-3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole

: 1616235-87-0
N-(6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; water; at 80 ℃; for 8h; Inert atmosphere;

Reference yield:

: 1616235-82-5
5-(3,6-dihydro-2H-pyran-4-yl)-3-(4-fluorophenyl)-1-methyl-1H-pyrazole

: 1616235-87-0
N-(6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium on activated charcoal; hydrogen / methanol / 8 h / Inert atmosphere

2: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; potassium phosphate / 1,4-dioxane; water / 8 h / 80 °C / Inert atmosphere

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; palladium on activated charcoal; hydrogen; XPhos; In 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 1616235-79-0
3,3-dibromo-1-(4-fluorophenyl)prop-2-en-1-one

: 1616235-87-0
N-(6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / tetrahydrofuran / 16 h / 20 °C / Molecular sieve

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / 1,4-dioxane; water / 8 h / 80 °C / Inert atmosphere

3: palladium on activated charcoal; hydrogen / methanol / 8 h / Inert atmosphere

4: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

5: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; potassium phosphate / 1,4-dioxane; water / 8 h / 80 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; palladium on activated charcoal; hydrogen; triethylamine; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;