Technology Process of 3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-4-(dimethylamino)benzonitrile
There total 9 articles about 3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-4-(dimethylamino)benzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 3h;
Inert atmosphere;
DOI:10.1016/j.bmc.2014.03.022
- Guidance literature:
-
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C / Inert atmosphere
2: acetic acid / 1,2-dichloro-ethane / 2 h / 120 °C / Inert atmosphere; Sealed tube
3: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere
With
sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; acetic acid;
In
tetrahydrofuran; methanol; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2014.03.022
- Guidance literature:
-
Multi-step reaction with 4 steps
1: ammonium acetate / methanol; tert-butyl methyl ether; water / 4 h / 20 °C
2: hydrogenchloride / water / 4 h / 70 °C
3: acetic acid / 1,2-dichloro-ethane / 2 h / 120 °C / Inert atmosphere; Sealed tube
4: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere
With
hydrogenchloride; sodium tetrahydroborate; ammonium acetate; acetic acid;
In
tetrahydrofuran; methanol; tert-butyl methyl ether; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2014.03.022
